急性心肌梗死（AMI）同时患有消化系统疾病的患者比没有这些疾病的患者更容易患上胃肠道（GI）出血。然而，很少有文章报告消化道不同疾病状况对GI出血产生不同风险的情况。本研究回顾性检查了北京朝阳心脏中心从2010年12月到2019年6月收治的7464例AMI患者的单中心研究。将出现重大GI出血的患者（n = 165）与没有出现重大GI出血的患者（n = 7299）进行比较。构建单变量和多变量 logistic 回归模型以测试GI出血与消化道前期疾病（包括胃食管反流病、慢性胃炎、消化性溃疡、肝功能损伤、结肠和直肠疾病以及胃肠道肿瘤）之间的关联。在7464名患者中（平均年龄63.4岁；女性25.6%；STEMI 58.6%），165人（2.2%）经历了重大GI出血，1816人（24.3%）有消化系统疾病史。通过多元 logistic 回归分析，消化性溃疡（OR = 4.19，95% CI: 1.86-9.45）和胃肠道肿瘤（OR = 2.74，95% CI: 1.07-7.04）与GI出血的风险显著相关。AMI患者中既往存在的消化性溃疡和胃肠道肿瘤，而非其他消化系统疾病，是标志着患者在住院期间进行标准抗血栓治疗时患有胃肠道出血的指标。©2021刘等。

Patients presenting with acute myocardial infarction (AMI) with prior digestive system disease are more likely to suffer from gastrointestinal (GI) bleeding than those without these diseases. However, few articles reported how the different conditions of the digestive tract produced different risks of GI bleeding.A single-center study on 7464 patients admitted for AMI from December 2010 to June 2019 in the Beijing Chaoyang Heart Center was retrospectively examined. Patients with major GI bleeding (n = 165) were compared with patients without (n = 7299). Univariate and multivariate logistic regression models were constructed to test the association between GI bleeding and prior diseases of the digestive tract, including gastroesophageal reflux disease, chronic gastritis, peptic ulcer, hepatic function damage, diseases of the colon and rectum, and gastroenterological tract tumors.Of the 7464 patients (mean age, 63.4; women, 25.6%; STEMI, 58.6%), 165 (2.2%) experienced major GI bleeding, and 1816 (24.3%) had a history of digestive system disease. The risk of GI bleeding was significantly associated with peptic ulcer (OR = 4.19, 95% CI: 1.86-9.45) and gastroenterological tumor (OR = 2.74, 95% CI: 1.07-7.04), indicated by multivariate logistic regression analysis.Preexisting peptic ulcers and gastroenterological tract tumors rather than other digestive system diseases were indicators of gastrointestinal bleeding in patients with AMI who undergo standard antithrombotic treatment during hospitalization.© 2021 Liu et al.