癌症是一系列由基因组层面特定变化所致，支持细胞无限增殖的疾病集合。传统上，离子通道被认为可控制各种细胞过程，包括通过控制离子梯度来生成和传输电信号、分泌和收缩。然而，最近的研究揭示了离子通道在癌症生物学中的重要作用。在本文中，我们将讨论钾或氯离子通道活性与控制癌细胞增殖的生化途径之间的机制，并探讨将离子通道作为抗癌治疗选择的潜在优势。©2021. Springer Nature Switzerland AG.

Cancer is a collection of diseases caused by specific changes at the genomic level that support cell proliferation indefinitely. Traditionally, ion channels are known to control a variety of cellular processes including electrical signal generation and transmission, secretion, and contraction by controlling ionic gradients. However, recent studies had brought to light important facts on ion channels in cancer biology.In this review we discuss the mechanism linking potassium or chloride ion channel activity to biochemical pathways controlling proliferation in cancer cells and the potential advantages of targeting ion channels as an anticancer therapeutic option.© 2021. Springer Nature Switzerland AG.