新型冠状病毒疾病2019（COVID-19）由严重急性呼吸系统综合症冠状病毒-2（SARS-CoV-2）引起，对全球的健康和经济系统造成了挑战。在某些人群中，COVID-19可以引起各种症状，影响多个器官，如肺、心脏、肠道、肾脏和大脑，导致多器官衰竭、败血症和死亡。这些影响部分与这些器官的直接病毒感染、免疫调节紊乱、高凝状态以及细胞因子风暴综合征的潜在发展有关。由于COVID-19的出现是最近的，恢复患者健康的长期影响仍然未知。在这篇综述中，我们关注了研究DNA损伤机制的当前证据。数据支持这些病毒在哺乳动物细胞中复制时会诱导DNA损伤、基因组不稳定性和细胞周期紊乱。由于DNA损伤和异常DNA修复机制的诱导与慢性疾病的发展，如癌症、糖尿病、神经退行性疾病和动脉硬化有关，因此有必要解决恢复COVID-19患者中类似的影响和结果。版权所有©2022 Elsevier B.V.。保留所有权利。

The coronavirus disease-2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is challenging global health and economic systems. In some individuals, COVID-19 can cause a wide array of symptoms, affecting several organs, such as the lungs, heart, bowels, kidneys and brain, causing multiorgan failure, sepsis and death. These effects are related in part to direct viral infection of these organs, immunological deregulation, a hypercoagulatory state and the potential for development of cytokine storm syndrome. Since the appearance of COVID-19 is recent, the long-term effects on the health of recovered patients remain unknown. In this review, we focused on current evidence of the mechanisms of DNA damage mediated by coronaviruses. Data supports that these viruses can induce DNA damage, genomic instability, and cell cycle deregulation during their replication in mammalian cells. Since the induction of DNA damage and aberrant DNA repair mechanisms are related to the development of chronic diseases such as cancer, diabetes, neurodegenerative disorders, and atherosclerosis, it will be important to address similar effects and outcomes in recovered COVID-19 patients.Copyright © 2022 Elsevier B.V. All rights reserved.