鼻腔恶性肿瘤占所有头颈恶性肿瘤的<5％，发病率为每10万人口0.5-1.0。这些罕见恶性肿瘤的预后较差，而其他癌症的治疗方面已取得了显著进展。本次综述的目的是描述鼻腔道恶性肿瘤的发病率、病因、临床表现、诊断、治疗和最新进展。此综述涵盖了鼻腔未分化癌、鼻腔腺癌、鼻腔鳞状细胞癌和嗅上皮神经母细胞瘤等鼻腔道专属疾病的诊断。此外，作者还涉及了在鼻腔道容易遇到的恶性肿瘤，如原发性粘膜黑色素瘤、NUT（睾丸核蛋白）癌和外周自然杀伤细胞/T细胞淋巴瘤。为了使本综述保持简洁而集中的目的，本文不包括被归类为唾液腺肿瘤的肉瘤和恶性肿瘤。 © 2022作者。由Wiley Periodicals LLC代表美国癌症学会出版的《CA:癌症临床》杂志。

Sinonasal malignancies make up <5% of all head and neck neoplasms, with an incidence of 0.5-1.0 per 100,000. The outcome of these rare malignancies has been poor, whereas significant progress has been made in the management of other cancers. The objective of the current review was to describe the incidence, causes, presentation, diagnosis, treatment, and recent developments of malignancies of the sinonasal tract. The diagnoses covered in this review included sinonasal undifferentiated carcinoma, sinonasal adenocarcinoma, sinonasal squamous cell carcinoma, and esthesioneuroblastoma, which are exclusive to the sinonasal tract. In addition, the authors covered malignances that are likely to be encountered in the sinonasal tract-primary mucosal melanoma, NUT (nuclear protein of the testis) carcinoma, and extranodal natural killer cell/T-cell lymphoma. For the purpose of keeping this review as concise and focused as possible, sarcomas and malignancies that can be classified as salivary gland neoplasms were excluded.© 2022 The Authors. CA: A Cancer Journal for Clinicians published by Wiley Periodicals LLC on behalf of American Cancer Society.