黑人患者的黑色素瘤预后不良。由于罕见，这个人群中的黑色素瘤没有得到很好的描述。本研究评估了黑人患者黑色素瘤的生存预测因素。这是一项对2004-2018年国家癌症数据库中患有皮肤黑色素瘤的黑人患者的回顾性队列研究。在2464例病例中，女性黑色素瘤比男性更常见（57.1% vs. 42.9%，p < .001）。布雷斯洛深度中位数为1.8 mm（四分位距0.4-4.4）。下肢是最常见的部位（52.8%），其次是上肢（13.1%），其他指定/重叠/其他（13.1%），然后是躯干（11.8%），最后是头颈部（9.2%）。诊断时期分别为I期（30.7%），II期（27.5%），III期（24.1%）和IV期（17.7%）。溃疡出现在41.4%的病变中。扁平锯齿形黑色素瘤（ALM）是最常见的具体组织学亚型（20.3%），其次是表浅扩展型黑色素瘤（9.4%）。在调整混杂因素后，高期和头颈部原发部位是最强的独立预测因素，能预测更差的总体生存率。黑人患者的黑色素瘤最有可能出现在下肢。大部分病例（41.8%）表现为III或IV期疾病。ALM是最常见的具体组织学亚型。©2022年约翰·威立·儿子公司。由约翰·威立·儿子有限公司发表。

Melanoma in Black patients carries a poor prognosis. Due to its rarity, melanoma in this population has not been well characterized. This study evaluates survival predictors in Black patients with melanoma. This was a retrospective cohort study of Black patients with cutaneous melanoma from the National Cancer Database 2004-2018. Of the 2464 cases, melanoma was more common among females than males (57.1% vs. 42.9%, p < .001). Median Breslow depth was 1.8 mm (interquartile range 0.4-4.4). Lower extremities were the most common location (52.8%), followed by upper extremities (13.1%) along with otherwise specified/overlapping/other (13.1%), then by trunk (11.8%), and lastly head and neck (9.2%). Stage at diagnosis was I (30.7%), II (27.5%), III (24.1%), and IV (17.7%). Ulceration was observed in 41.4% of lesions. Acral lentiginous melanoma (ALM) was the most common specific histologic subtype (20.3%), followed by superficial spreading melanoma (9.4%). After adjusting for confounders, higher stages and primary site on the head and neck were the strongest independent predictors of worse overall survival. Melanoma in Black patients is most likely to appear on the lower extremities. A large portion (41.8%) presented with stage III or IV disease. ALM was the most common specific histologic subtype.© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.