鳞状细胞癌是口腔和其邻近部位最常见的恶性肿瘤，危及患者的身体和心理健康，其病因复杂。慢性感染被认为是癌症发展的风险因素。证据表明，牙周病原菌，如紫色链球菌，核酸纤维菌和牙齿螺旋体等与口腔鳞状细胞癌（OSCC）有关。它们可以通过促进上皮细胞增殖，抑制细胞凋亡和调节炎性微环境而刺激肿瘤发生。白色念珠菌通过多种机制促进OSCC的进展和转移。此外，口腔人乳头瘤病毒（HPV）可以引起咽喉鳞状细胞癌（OPSCC）。有证据表明，HPV16可以与宿主细胞DNA整合并激活癌基因。此外，口腔微生物群落的失调和协同作用可以促进癌症发展。在本综述中，我们将讨论与OSCC和OPSCC有关的口腔微生物组的生物学特性，然后重点介绍口腔微生物组参与口腔肿瘤发生、肿瘤进展和转移的机制。这些发现可能对口腔癌的早期诊断和治疗具有积极意义。©2022 John Wiley＆Sons A / S。John Wiley＆Sons Ltd.发表。

Squamous cell carcinoma is the most common malignant tumor of the oral cavity and its adjacent sites, which endangers the physical and mental health of patients and has a complex etiology. Chronic infection is considered to be a risk factor in cancer development. Evidence suggests that periodontal pathogens, such as Porphyromonas gingivalis, Fusobacterium nucleatum, and Treponema denticola, are associated with oral squamous cell carcinoma (OSCC). They can stimulate tumorigenesis by promoting epithelial cells proliferation while inhibiting apoptosis and regulating the inflammatory microenvironment. Candida albicans promotes OSCC progression and metastasis through multiple mechanisms. Moreover, oral human papillomavirus (HPV) can induce oropharyngeal squamous cell carcinoma (OPSCC). There is evidence that HPV16 can integrate with host cells' DNA and activate oncogenes. Additionally, oral dysbiosis and synergistic effects in the oral microbial communities can promote cancer development. In this review, we will discuss the biological characteristics of oral microbiome associated with OSCC and OPSCC and then highlight the mechanisms by which oral microbiome is involved in oral oncogenesis, tumor progression, and metastasis. These findings may have positive implications for early diagnosis and treatment of oral cancer.© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.