成千上万的基因被癌症扰动，这些扰动可以在转录组、甲基化、体细胞突变和拷贝数变异组学研究中看到。在分子相互作用网络 (相互作用组) 中了解它们的连接模式作为一个全基因组邻域是推进了解癌症分子机制的关键一步。在这里，我们引入了一个统一连接线 (CLine)，以定位跨越15种精选癌症的组学特异性全基因组模式。利用CLine的通用性，我们区分了每个组学方面的外周和核心基因。我们提出了一个基于网络的框架，多组学周缘和核心 (MOPC)，将不同组学的外周和核心基因融合成一个类似按键的结构。根据网络距离的基础上，我们提供了证据表明核心基因 tend to 是在一个组学中特别受到扰动，但外围基因在多个组学中受到不同的扰动。而一个组学的核心由多个组学的周缘调节。最后，我们将MOPC作为全基因组邻域，描述它的特点，并探讨其对网络化癌症机制的相对贡献。我们能够展示多组学扰动如何在人类相互作用组中渗透，并为综合周缘和核心做出贡献。©2022。作者。

Thousands of genes are perturbed by cancer, and these disturbances can be seen in transcriptome, methylation, somatic mutation, and copy number variation omics studies. Understanding their connectivity patterns as an omnigenic neighbourhood in a molecular interaction network (interactome) is a key step towards advancing knowledge of the molecular mechanisms underlying cancers. Here, we introduce a unified connectivity line (CLine) to pinpoint omics-specific omnigenic patterns across 15 curated cancers. Taking advantage of the universality of CLine, we distinguish the peripheral and core genes for each omics aspect. We propose a network-based framework, multi-omics periphery and core (MOPC), to combine peripheral and core genes from different omics into a button-like structure. On the basis of network proximity, we provide evidence that core genes tend to be specifically perturbed in one omics, but the peripheral genes are diversely perturbed in multiple omics. And the core of one omics is regulated by multiple omics peripheries. Finally, we take the MOPC as an omnigenic neighbourhood, describe its characteristics, and explore its relative contribution to network-based mechanisms of cancer. We were able to present how multi-omics perturbations percolate through the human interactome and contribute to an integrated periphery and core.© 2022. The Author(s).