在全球范围内，探索有效的系统性肝癌治疗仍然是一个巨大的挑战。作为一种新型的调节性细胞死亡形式，铁死亡在癌症研究领域越来越受到关注。近年来，针对铁死亡成为了肝癌治疗的一种有希望的策略。引导铁死亡可直接杀死癌细胞；相反，铁死亡也可改善肿瘤免疫抑制微环境并增强免疫治疗的癌症敏感性。在此，我们全面总结了肝脏中铁稳态的当前进展、铁稳态失衡与肝癌发生和发展的内在关联，以及肝癌中的铁死亡相关调节因子。此外，我们深入讨论了铁死亡与肿瘤免疫微环境的相互作用。最后，我们确信地提供了铁死亡在肝癌免疫治疗中的潜在价值的未来展望。版权©2023 Elsevier B.V.保留所有权利。

Exploring effective systemic treatments for liver cancer is still a great challenge worldwide. As a novel form of regulated cell death, ferroptosis has been paid more and more attention in the cancer research field. In recent years, targeting ferroptosis has become an encouraging strategy for liver cancer treatment. Cancer cells can be directly killed by inducing ferroptosis; in contrast, ferroptosis can also ameliorate the tumor immunosuppressive microenvironment and sensitize cancers to immunotherapy. Here, we summarize fully current progress in the iron homeostasis in the liver, the internal association between imbalanced iron homeostasis and ferroptosis in liver carcinogenesis and development, as well as ferroptosis-related regulators in liver cancer. Furthermore, we discuss thoroughly the interaction between ferroptosis and tumor immune microenvironment. Finally, we provide certainly a future insight on the potential value of ferroptosis in the immunotherapy of liver cancer.Copyright © 2023 Elsevier B.V. All rights reserved.