几十年来，超温疗法单独或与放疗和/或化疗相结合对于各种肿瘤类型的潜在抗肿瘤作用一直是动物实验和临床研究的热点。本文总结了针对表浅性非肌层侵犯性膀胱癌的膀胱内甲氨蝶呤与超温疗法以及应用于深部区域的微波超温疗法技术在外照射放疗或药物放疗治疗更晚期肿瘤的修饰效应的临床证据。在某些组的结果中，初步经过经尿道切除术和以顺铂为基础的化疗放疗，再结合深部区域超温疗法，则可以使五年总生存率提高20％。给出的数据证明，在多模式膀胱保育前瞻性试验的背景下，对于轻微的局部超温疗法，有重新考虑的机会。版权所有 © 2022 Elsevier Inc.保留所有权利。

For decades, the antineoplastic potential of hyperthermia alone or in combination with radiotherapy and/or chemotherapy has been subject of intensive preclinical and clinical research in various tumor entities. The clinical evidence on the beneficial effects of additional hyperthermia in combination with intravesical Mitomycin C for superficial non-muscle-invasive bladder cancer as well as for deep regional microwave hyperthermia techniques applied during an external beam radiotherapy or chemoradiation treatment for more advanced tumors are summarized. In some series, deep regional hyperthermia in combination with an initial transurethral resection and Cisplatin-based chemoradiation increased the 5-year overall survival rates up to 20%. The presented data justifies a fresh irrespective chance for mild regional hyperthermia in the context of new progressive prospective trials on multimodality treatment for bladder preservation.Copyright © 2022 Elsevier Inc. All rights reserved.