在美国，前列腺癌是男性最常见的癌症，也是第二大癌症死因。与白人相比，黑人的发病率更高且死亡率更高。我们比较了1999年至2019年美国不同种族和州的前列腺癌死亡率趋势。我们使用国际疾病分类（ICD）10代码C61从疾病控制中心（CDC）WONDER数据库中提取前列腺癌死亡数据。按年份和州分组将年龄标准死亡率（ASMR）分为种族组并报告。由于许多州缺乏可用数据，因此仅针对白人和黑人使用Joinpoint回归进行趋势比较分析。在1999年至2019年期间，黑人（-44.6％），亚洲人（-44.8％），白人（-31.8％）和美洲印第安人或阿拉斯加原住民男性（-19.0％）的ASMR在全国范围内下降。对于两种种族，所有州的ASMR都有所下降。 WM的ASMR最大下降为肯塔基州（-47.0％），而BM的ASMR最大下降为特拉华州（-57.8％）。 2019年，BM的ASMR（13.4/100,000）明显高于WM（7.3/100,000）、美洲印第安人或阿拉斯加本土居民（3.2/100,000）和亚洲男性（3.2/100,000）（p <0.001）。 BM的ASMR最高是在内布拉斯加州（33.5/100,000），而WM最高是在阿拉斯加州（11/100,000）。在过去的20年中，所有种族的所有州的前列腺癌死亡率都有所下降，这表明了管理策略的进步。尽管BM的ASMR下降较大，但BM的ASMR仍然更高。在许多州中，自美国癌症筛查工作组指南更改之后（2012），ASMR也呈上升趋势，说明需要更多关于前列腺癌筛查的教育。 ©2022年作者（独家许可Springer Nature Limited）

In the United States of America (USA), prostate cancer (PC) is the most common cancer in men and the second cause of cancer mortality. Black men (BM) have a higher incidence and worse mortality when compared to white men (WM). We compared trends in PC mortality in the USA by race and state from 1999 to 2019.We extracted PC mortality data from the Centers for Disease Control (CDC) WONDER database using the International Classification of Diseases (ICD) 10 code C61. Age-Standardized Mortality Rates (ASMR) were divided into racial groups and reported by year and state. Due to the lack of available data in many states, analyses were conducted only for WM and BM using Joinpoint regression for trend comparisons.Between 1999-2019, ASMR decreased at the national level in Black (-44.6%), Asian (-44.8%), White (-31.8%), and American Indian or Alaskan native men (-19.0%). ASMR decreased in all states for both races. The greatest drop in ASMR was in Kentucky (-47.0%) for WM and Delaware (-57.8%) for BM. In 2019, ASMRs in BM (13.4/100 000) were significantly higher than WM (7.3/100 000), American Indian or Alaskan Native (3.2/100 000), and Asian men (3.2/100 000) (p < 0.001). The highest ASMRs were in Nebraska (33.5/100 000) for BM and Alaska (11/100 000) for WM.During the last 20 years, the PC mortality rate dropped in all states for all races, suggesting an advancement in management strategies. Although a higher decrease in ASMR was observed in BM, ASMR remain higher among BM. ASMRs were also found to be increasing in many states post USPSTF guideline change (2012), indicating a need for more education around optimized prostate cancer screening.© 2022. The Author(s), under exclusive licence to Springer Nature Limited.