胰管内乳头状粘液性肿瘤（IPMNs）和黏液性囊性肿瘤（MCNs）都被认为是“胰腺囊性肿瘤（PCNs）”，并显示出发展成胰管腺癌（PDAC）的不同风险。这些病变显示出不同的分子特征、突变和临床表现。对PCN亚型特征及其分子机制的缺乏详细理解限制了这些病变的有效诊断工具和治疗策略的开发。还需要适当的体内小鼠模型来模拟人类PCNs以研究分子机制和治疗测试。全面了解PCN生物学、机制、当前诊断方法和治疗方案的现状将有助于早期发现和正确管理这些病变和PDAC的患者。本文旨在通过描述未来展望来描述PCNs方面的所有这些方面，特别是IPMNs。 版权所有©2022 Elsevier B.V。保留所有权利。

Intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs) are all considered "Pancreatic cystic neoplasms (PCNs)" and show a varying risk of developing into pancreatic ductal adenocarcinoma (PDAC). These lesions display different molecular characteristics, mutations, and clinical manifestations. A lack of detailed understanding of PCN subtype characteristics and their molecular mechanisms limits the development of efficient diagnostic tools and therapeutic strategies for these lesions. Proper in vivo mouse models that mimic human PCNs are also needed to study the molecular mechanisms and for therapeutic testing. A comprehensive understanding of the current status of PCN biology, mechanisms, current diagnostic methods, and therapies will help in the early detection and proper management of patients with these lesions and PDAC. This review aims to describe all these aspects of PCNs, specifically IPMNs, by describing the future perspectives.Copyright © 2022 Elsevier B.V. All rights reserved.