造血干细胞移植（HCT）是治疗恶性肿瘤和一些非恶性疾病的复杂治疗方法。由于患者和流程相关的障碍，HCT的知情同意过程也可能很复杂。知情同意过程需要是动态和持续的过程，而不仅仅是一个清单。由于HCT的现实，我们强调了知情同意过程可能存在的一些潜在问题，包括不确定性、社会文化和交流障碍以及决策后悔。这个全面的综述的目的是突出可能导致知情同意过程失败的独特情况。我们还提供了潜在的解决方案，主要是通过动态和连续的过程使知情同意更加关注患者，以减轻决策后悔。版权所有©2022 Elsevier Ltd.

Hematopoietic cell transplantation (HCT) is a complex treatment used in malignancies and some non-malignant diseases. The informed consent process for HCT can also be complex due to patient- and process-related barriers. The informed consent process needs to be a dynamic and ongoing process, not simply a checklist. As a result of the realities of HCT, we highlight some potential pitfalls to the informed consent process including uncertainty, sociocultural and communication barriers, and decisional regret. The purpose of this comprehensive review is to highlight unique situations which can result in failure of the informed consent process. We also offer potential solutions to these pitfalls, primarily making the informed consent more patient focused through dynamic and continuous processes to mitigate decisional regret.Copyright © 2022 Elsevier Ltd. All rights reserved.