维生素 D 系统在皮肤癌发生中的作用存在互相矛盾的结果。因此，本研究调查了口服维生素 D 补充剂的使用是否与光老化、日光性角化病、色素细胞痣和皮肤癌相关。在这项横断面研究中，检查了498名成年人（年龄在21-79岁之间,男性253名，女性245名，96名有免疫抑制）患有任何类型皮肤癌风险的人，并评估了可能的混淆因素。根据自我报告的口服维生素 D 补充剂使用情况，将研究对象分为三组：不使用、偶尔使用或定期使用。在260名受试者中分析了25-羟基维生素 D3 的血清水平。在402名免疫能力正常的受试者中，维生素 D 的使用与光老化、日光性角化病、痣、基底细胞癌和鳞状细胞癌无关。相反，与非使用者相比，定期使用者中患有过去或现在的黑色素瘤（32/177，18.1% 对 32/99，32.3%，P = 0.021）或任何类型的皮肤癌（110/177，62.1% 对 74/99，74.7%，P = 0.027）的受试者比例较低。在逻辑回归分析中，黑色素瘤的几率比为 0.447（P = 0.016，95% 置信区间为 0.231-0.862）在定期使用者中。此外，研究者估计的皮肤癌风险分类在定期使用者中显著较低。血清25-羟基维生素 D3 与皮肤相关参数没有明显的关联。96名免疫抑制受试者的结果有些类似，但受试者人数较少。总之，与非使用者相比，定期使用维生素 D 与更少的黑色素瘤病例相关，但它们之间的因果关系尚不清楚。版权所有©2022 Wolters Kluwer Health, Inc.。保留所有权利。

There are conflicting results on the role of vitamin D system in cutaneous carcinogenesis. Therefore, it was investigated whether the use of oral vitamin D supplements associates with photoaging, actinic keratoses, pigment cell nevi, and skin cancers. In this cross-sectional study, 498 adults (aged 21-79 years, 253 males, 245 females, 96 with immunosuppression) subjects at risk of any type of skin cancer were examined, and possible confounding factors were evaluated. The subjects were divided into three groups based on their self-reported use of oral vitamin D supplements: non-use, occasional use, or regular use. The serum level of 25-hydroxyvitamin-D3 was analyzed in 260 subjects. In 402 immunocompetent subjects, vitamin D use did not associate with photoaging, actinic keratoses, nevi, basal, and squamous cell carcinoma. In contrast, there were lower percentages of subjects with a history of past or present melanoma (32/177, 18.1% versus 32/99, 32.3%, P  = 0.021) or any type of skin cancer (110/177, 62.1% versus 74/99, 74.7%, P  = 0.027) among regular users compared to non-users. In the logistic regression analysis, the odds ratio for melanoma was 0.447 ( P  = 0.016, 95% confidence interval, 0.231-0.862) among regular users. Furthermore, the investigator-estimated risk class of skin cancers was significantly lower among regular users. Serum 25-hydroxyvitamin-D3 did not show marked associations with skin-related parameters. The results on 96 immunosuppressed subjects were somewhat similar, although the number of subjects was low. In conclusion, regular use of vitamin D associates with fewer melanoma cases, when compared to non-use, but the causality between them is obscure.Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.