比较CT影像学特征在肺腺癌患者中的应用，这些患者被诊断出有肿瘤细胞通过空气间隙蔓延（STAS阳性【STAS +】）和那些没有STAS的患者。系统地搜索PubMed、Embase和Scopus数据库中回顾性或前瞻性的肺腺癌患者的观察性研究，比较STAS +和STAS-病例之间的基于CT的特征。汇总效应大小报告为比值比（OR）和加权平均差异（WMD）。使用STATA软件进行统计分析。荟萃分析包括10个研究。与STAS-相比，STAS +腺癌与实性结节（OR：3.30，95％CI：2.52，4.31），星芒状结节（OR：2.05，95％CI：1.36，3.08），空洞（OR：1.49，95%CI：1.00，2.22），明显边界（OR：3.01，95% CI：1.70，5.32），分叶（OR：1.65，95％CI：1.11，2.47）和胸膜凹陷（OR：1.98，95％CI：1.41，2.77）的实体化有显著增加的几率。STAS +肿瘤与肺血管汇聚（OR：2.15，95%CI：1.61，2.87），纵隔淋巴结肿大（OR：2.06，95%CI：1.20，3.56）和胸膜增厚（OR：2.58，95%CI：1.73，3.84）等有显著关联。与STAS-相比，STAS +肿瘤的平均结节直径（mm）（WMD：6.19，95％CI：3.71，8.66）和平均实性成分（％）（WMD：24.5，95％CI：10.5，38.6）均较高。结果表明，在肺腺癌患者中，某些基于CT的特征与STAS的存在显著相关。这些特征可能对手术管理的性质有重要影响。 版权所有©2022作者。 Wolters Kluwer Health,Inc.出版。

To compare computed tomography (CT)-based radiologic features in patients, who are diagnosed with lung adenocarcinoma with the pathologically detected spread of tumor cells through air spaces (STAS positive [STAS+]) and those with no STAS. PubMed, Embase, and Scopus databases were systematically searched for observational studies (either retrospective or prospective) of patients with lung adenocarcinoma that had compared CT-based features between STAS+ and STAS-negative cases (STAS-). The pooled effect sizes were reported as odds ratio (OR) and weighted mean difference (WMD). STATA software was used for statistical analysis. The meta-analysis included 10 studies. Compared with STAS-, STAS+ adenocarcinoma was associated with increased odds of solid nodule (OR: 3.30, 95% CI: 2.52, 4.31), spiculation (OR: 2.05, 95% CI: 1.36, 3.08), presence of cavitation (OR: 1.49, 95% CI: 1.00, 2.22), presence of clear boundary (OR: 3.01, 95% CI: 1.70, 5.32), lobulation (OR: 1.65, 95% CI: 1.11, 2.47), and pleural indentation (OR: 1.98, 95% CI: 1.41, 2.77). STAS+ tumors had significant association with the presence of pulmonary vessel convergence (OR: 2.15, 95% CI: 1.61, 2.87), mediastinal lymphadenopathy (OR: 2.06, 95% CI: 1.20, 3.56), and pleural thickening (OR: 2.58, 95% CI: 1.73, 3.84). The mean nodule diameter (mm) (WMD: 6.19, 95% CI: 3.71, 8.66) and the mean solid component (%) (WMD: 24.5, 95% CI: 10.5, 38.6) were higher in STAS+ tumors, compared with STAS- ones. The findings suggest a significant association of certain CT-based features with the presence of STAS in patients with lung adenocarcinoma. These features may be important in influencing the nature of surgical management.Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.