癌干细胞（CSCs）现在被认为是肿瘤起始、发展、转移和复发的主要“种子”。尽管治疗取得了突破，癌症仍然是全球主要死因。这是因为肿瘤微环境包含着一个关键的细胞群体，称为CSCs，它们促进肿瘤侵略性。CSCs是自我更新的细胞，通过促进肿瘤生长和在许多传统癌症治疗后在患者体内存活来帮助肿瘤复发。根据报道，许多转录因子（TF）在维持CSC多能性及其自我更新属性方面发挥关键作用。对这些转录因子的功能、结构和相互作用动力学的理解改变了假设，为新型转录因子靶向治疗铺平道路。这些对癌细胞至关重要且必需的TF在人类癌症的病因学中发挥关键作用。这些CSC TFs将有助于基因表达谱的基因表达谱中预测患者预后的关键数据。为了克服抗癌药物的耐药性并彻底根治癌症，可以开发一种强效的治疗方法，将基于TFs的CSC靶点与传统化疗结合起来。为了开发可以消除CSCs的疗法，我们在这里集中关注TFs和信号通路其他组分对癌症干性的影响。版权所有©2023 Elsevier Ltd.

Cancer Stem Cells (CSCs) are now considered the primary "seeds" for the onset, development, metastasis, and recurrence of tumors. Despite therapeutic breakthroughs, cancer remains the leading cause of death worldwide. This is because the tumor microenvironment contains a key population of cells known as CSCs, which promote tumor aggression. CSCs are self-renewing cells that aid tumor recurrence by promoting tumor growth and persisting in patients after many traditional cancer treatments. According to reports, numerous transcription factors (TF) play a key role in maintaining CSC pluripotency and its self-renewal property. The understanding of the functions, structures, and interactional dynamics of these transcription factors with DNA has modified the hypothesis, paving the way for novel transcription factor-targeted therapies. These TFs, which are crucial and are required by cancer cells, play a vital function in the etiology of human cancer. Such CSC TFs will help with gene expression profiling, which provides crucial data for predicting the prognosis of patients. To overcome anti-cancer medication resistance and completely eradicate cancer, a potent therapy combining TFs-based CSC targets with traditional chemotherapy may be developed. In order to develop therapies that could eliminate CSCs, we here concentrated on the effect of TFs and other components of signalling pathways on cancer stemness.Copyright © 2023 Elsevier Ltd. All rights reserved.