新的读者和写作者对于白血病干细胞独特的RNA修饰。
New readers and writers of RNA modifications unique to leukemia stem cells.
发表日期：2023 Jan 05
作者：
Takeshi Fujino, Omar Abdel-Wahab
来源：
Cell Stem Cell
摘要：
RNA的化学修饰经由一系列的阅读器、写入器和擦除器调控基因表达。细胞干细胞学的两份最新研究1,2揭示了N6-甲基腺嘌呤(m6A)甲基转移酶METTL16和m6A阅读器IGF2BP2在引发白血病的细胞中所扮演的角色，为白血病开辟了令人振奋的新治疗靶点。Copyright © 2022 Elsevier Inc. All rights reserved.
Chemical modifications of RNA are regulated by a series of readers, writers, and erasers that dictate gene expression. Two new studies in Cell Stem Cell1,2identify roles for the N6-methyladenosine (m6A) methyltransferase METTL16 and the m6A reader IGF2BP2 in leukemia-initiating cells, illuminating exciting new therapeutic targets for leukemia.Copyright © 2022 Elsevier Inc. All rights reserved.