树突状细胞由于其激活细胞毒性效应CD8 + T细胞的能力，在抗肿瘤免疫应答中至关重要。在抗肿瘤免疫中，树突状细胞通过被称为交叉呈递过程激活CD8 + T细胞。最近的研究表明，另一种抗原呈递方式MHC加装也能够激活针对肿瘤细胞源性抗原的CD8 + T细胞。了解MHC加装对抗肿瘤免疫的特定贡献可以开辟新的治疗途径。 在本文中，我们总结了最早发现MHC加装作为相关抗原呈递通路的研究，然后深入探讨MHC加装的生物学，重点关注哪些树突状细胞亚群最能够执行MHC加装以及MHC加装与其他抗原呈递形式的比较。最后，我们讨论了MHC加装对于抗肿瘤免疫的意义。 版权 © 2023 Elsevier Ltd. 保留所有权利。

Dendritic cells are crucial for anti-tumor immune responses due to their ability to activate cytotoxic effector CD8+ T cells. Canonically, in anti-tumor immunity, dendritic cells activate CD8+ T cells in a process termed cross-presentation. Recent studies have demonstrated that another type of antigen presentation, MHC-dressing, also serves to activate CD8+ T cells against tumor cell-derived antigens. Understanding MHC-dressing's specific contributions to anti-tumor immunity can open up novel therapeutic avenues. In this review, we summarize the early studies that identified MHC-dressing as a relevant antigen presentation pathway before diving into a deeper discussion of the biology of MHC-dressing, focusing in particular on which dendritic cell subsets are most capable of performing MHC-dressing and how MHC-dressing compares to other forms of antigen presentation. We conclude by discussing the implications MHC-dressing has for anti-tumor immunity.Copyright © 2023 Elsevier Ltd. All rights reserved.