设备评估的活动行为是比较恶性胸腔积液（MPE）患者治疗效果的一种新方法。澳大拉西亚恶性胸腔积液（AMPLE）-2是一项多中心临床试验，参与者接受留置胸膜导管治疗的MPE患者被随机分配为每天排液（DD）或症状导向性排液（SGD）治疗，治疗持续60天。我们的目的是描述MPE患者的活动行为模式，探讨排液方案对活动行为的影响，并研究活动行为与生活质量（QoL）之间的关系。在随机分配到DD或SGD后，参与者在主要试验中心（珀斯）完成了加速度计评估。这将每月重复5个月。活动行为结果计算为每日觉醒时间的百分比，并在组间进行比较（曼-惠特尼U检验；中位数[IQR]）。检查活动行为结果和QoL之间的相关性。41名（91％）参与者提供了≥1个有效的加速度计评估（DDn = 20，SGD n = 21）。参与者花费大部分觉醒时间于久坐状态（跨时间点分别为72％-74％），并很少进行中到剧烈的身体活动（跨时间点均＜1％）。与SGD组相比，DD组在随机分配后一周（2.4 [2.0-3.4] vs 3.2 [2.4-6.1]; p = 0.047）和60天（2.0 [1.9-2.9] vs 2.9 [2.8-6.0]; p = 0.016）具有更有利的久坐状态 - 轻微比率。久坐状态-轻微比率与多个时间点的多个QoL领域相关。MPE患者大多久坐。初步结果表明，即使是轻微的有利于DD组的活动行为差异对于这种临床人群也可能有意义。加速度计反映QoL，在MPE人群中是有用的结局措施。©2023年作者。Respirology由John Wiley＆Sons Australia，Ltd代表亚太呼吸学会出版。

Device-assessed activity behaviours are a novel measure for comparing intervention outcomes in patients with malignant pleural effusion (MPE). Australasian Malignant PLeural Effusion (AMPLE)-2 was a multi-centre clinical trial where participants with MPE treated with an indwelling pleural catheter were randomized to daily (DD) or symptom-guided (SGD) drainage for 60-days. Our aim was to describe activity behaviour patterns in MPE patients, explore the impact of drainage regimen on activity behaviours and examine associations between activity behaviours and quality of life (QoL).Following randomization to DD or SGD, participants enrolled at the lead site (Perth) completed accelerometry assessment. This was repeated monthly for 5-months. Activity behaviour outcomes were calculated as percent of daily waking-wear time and compared between groups (Mann-Whitney U test; Median [IQR]). Correlations between activity behaviour outcomes and QoL were examined.Forty-one (91%) participants provided ≥1 valid accelerometry assessment (DDn = 20, SGD n = 21). Participants spent a large proportion of waking hours sedentary (72%-74% across timepoints), and very little time in moderate-to-vigorous physical activity (<1% across timepoints). Compared to SGD group, DD group had a more favourable sedentary-to-light ratio in the week following randomization (2.4 [2.0-3.4] vs. 3.2 [2.4-6.1]; p = 0.047) and at 60-days (2.0 [1.9-2.9] vs. 2.9 [2.8-6.0]; p = 0.016). Sedentary-to-light ratio was correlated with multiple QoL domains at multiple timepoints.Patients with MPE are largely sedentary. Preliminary results suggest that even modest differences in activity behaviours favouring the DD group could be meaningful for this clinical population. Accelerometry reflects QoL and is a useful outcome measure in MPE populations.© 2023 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology.