人类结肠癌特异性抗原和拉曼光谱之间的相关性。试图利用拉曼光谱技术确定结肠癌肿瘤标志物。
Correlation between human colon cancer specific antigens and Raman spectra. Attempting to use Raman spectroscopy in the determination of tumor markers for colon cancer.
发表日期：2023 Feb
作者：
Joanna Depciuch, Paweł Jakubczyk, Wiesław Paja, Krzysztof Pancerz, Agnieszka Wosiak, Monika Kula-Maximenko, İlhan Yaylım, Güldal İnal Gültekin, Nevzat Tarhan, Mehmet Tolgahan Hakan, Dilara Sönmez, Devrim Sarıbal, Soykan Arıkan, Zozan Guleken
来源：
Nanomedicine
摘要：
结直肠癌是全球第二大致癌死亡原因。为了跟踪疾病的进展，通常使用肿瘤标志物。在这里，我们报告了基于拉曼光谱的血清分析，用于通过肿瘤标志物和使用ELİSA方法测量的两种新型细胞黏附分子提供快速的癌症诊断。拉曼光谱显示出来自CH2蛋白质和脂类、酰胺II和酰胺I以及CO脂质振动的1447厘米-1、1560厘米-1、1665厘米-1和1769厘米-1处的更高拉曼强度。此外，相关性测试表明，只有CEA结肠癌标志物与拉曼光谱相关。重要的是，机器学习方法显示，拉曼法在结肠癌检测方面的准确性约为95%。所获得的结果表明，1302厘米-1和1306厘米-1处的拉曼偏移可以用作结肠癌的光谱标志。版权所有 ©2023。由Elsevier Inc.出版。
Colorectal cancer is the second most common cause of cancer-related deaths worldwide. To follow up on the progression of the disease, tumor markers are commonly used. Here, we report serum analysis based on Raman spectroscopy to provide a rapid cancer diagnosis with tumor markers and two new cell adhesion molecules measured using the ELİSA method. Raman spectra showed higher Raman intensities at 1447 cm-1 1560 cm-1, 1665 cm-1, and 1769 cm-1, which originated from CH2 proteins and lipids, amide II and amide I, and CO lipids vibrations. Furthermore, the correlation test showed, that only the CEA colon cancer marker correlated with the Raman spectra. Importantly, machine learning methods showed, that the accuracy of the Raman method in the detection of colon cancer was around 95 %. Obtained results suggest, that Raman shifts at 1302 cm-1 and 1306 cm-1 can be used as spectroscopy markers of colon cancer.Copyright © 2023. Published by Elsevier Inc.