在癌症治疗方面已经取得了相当大的进展，但是，随着这些进展的出现，就会发现以前未知的不良事件。特别是，患者寿命的延长揭示了广泛使用的抗癌治疗的严重心脏毒性副作用，这限制了它们的使用，从而损害了似乎最适合大规模癌症患者群体的治疗方案的成功。相反，心血管疾病也可以促进不同癌症的发生和进展，这突显了两种疾病的深刻联系。认识到这些密切的相互作用，新的跨学科领域——心脏肿瘤学已经出现，以密切研究这些具有独特相互关联的疾病。在这方面，非编码RNA正受到越来越多的关注，因为它们构成许多生理和病理信号通路的关键调节因子，包括癌症和心脏功能障碍的通路。在本文中，我们着重介绍一个新的亚型非编码RNA——环状RNA，在心脏肿瘤学中的不同交换，并讨论它们作为治疗心脏功能障碍和癌症的强效靶点的适用性。©作者（2023）。由欧洲心脏病学学会代表牛津大学出版。保留所有权利。有关权限，请发送电子邮件至journals.permissions@oup.com。

Considerable progress has been made for managing cancer, however, with these advancements, comes the discovery of previously unknown adverse events. In particular, the prolonged lifespan of patients has uncovered severe cardiotoxic side effects of widely used anticancer therapies, which restrict their administration and thus compromise the success of the seemingly most suitable treatments in large cancer patient cohorts. Vice versa, cardiovascular diseases can also promote both the onset and progression of different cancers, highlighting that both conditions are deeply interlinked. Recognizing these close interactions, the novel interdisciplinary field of cardio-oncology has emerged to closely study these uniquely correlating diseases. In this regard, non-coding RNAs are gaining increasing attention since they constitute crucial regulators in many physiological but also pathological signaling pathways, including those of cancer and cardiac dysfunction. In this review, we focus on the new subtype of non-coding RNA, circular RNAs, in their distinct exchange within cardio-oncology and discuss their suitability as potent targets for the simultaneous treatment of cardiac dysfunction and cancer.© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.