胃癌（GC）局部转移手术切除仅针对没有其他不可治愈因素的患者进行弱推荐，这是日本GC治疗指南中的建议。虽然手术后化疗是二期或三期GC患者的标准治疗方法，但对于切除的四期GC的功效还不清楚。本研究旨在评估手术切除GC局部转移后术后化疗的疗效。我们在日本20家医疗机构回顾性地研究了2007年至2012年间被诊断为伴有同步性局部转移的GC的患者的病历记录。选择标准是：腺癌、四期肝或淋巴结局部转移且没有其他远处转移、包括同步局部转移的根治切除和手术前没有接受GC治疗。共收集到110名患者，其中94名符合选择标准，其中84名在胃切除手术中接受了手术切除局部转移（39例为肝转移[41％]，55例为淋巴结转移[59％]），然后接受了S-1（S1：n=55）、S1加顺铂（CS：n=22）或其他（n=7）手术后化疗。此外，10名患者没有接受术后化疗（非Cx）。手术切除后化疗组的中位总生存期（OS）为35.2个月，非Cx组为11.1个月（危险比为3.56，95％置信区间为1.74-7.30，p <0.001）。在多变量分析中，非Cx和年龄超过70岁被确定为OS的不良预后因素（p <0.05）。GC根治切除后接受术后化疗的患者表现出了有利的生存率。©2023作者们在The International Gastric Cancer Association和The Japanese Gastric Cancer Association的独家许可下发表。

Surgical resection of oligo-metastasis in gastric cancer (GC) is weakly recommended for patients without other incurable factors in the Japanese GC Treatment Guidelines. While post-operative chemotherapy is the standard treatment in patients with stage II or III GC, its efficacy for resected stage IV GC is unclear. This study aimed to evaluate the efficacy of post-operative chemotherapy after curative resection of GC with oligo-metastasis.We retrospectively reviewed the medical records of patients with GC who were diagnosed with synchronous oligo-metastasis at 20 institutions in Japan between 2007 and 2012. The selection criteria were: adenocarcinoma, stage IV with oligo-metastasis at liver or lymph node without other distant metastasis, curative resection including synchronous oligo-metastasis, and no prior treatment of GC before surgery.A total of 110 patients were collected. Of the 94 eligible patients, 84 underwent gastrectomy with surgical resection of oligo-metastasis (39 [41%] liver metastasis and 55, [59%] distant lymph node metastasis), followed by post-operative chemotherapy with S-1 (S1: n = 55), S1 plus cisplatin (CS: n = 22), or Others (n = 7). Moreover, 10 patients did not receive post-operative chemotherapy (Non-Cx). The median overall survival (OS) was 35.2 and 11.1 months in the post-operative chemotherapy and Non-Cx groups (hazard ratio, 3.56; 95% confidence interval, 1.74-7.30; p < 0.001), respectively. In multivariable analysis, Non-Cx and age over 70 years were identified as poor prognostic factors for OS (p < 0.05).Curative resection followed by post-operative chemotherapy in patients with GC with synchronous oligo-metastasis showed favorable survival.© 2023. The Author(s) under exclusive licence to The International Gastric Cancer Association and The Japanese Gastric Cancer Association.