转录因子（TF）是最常见的失调的与多种人类癌症相关的DNA结合类蛋白。它们可以作为转录激活因子或抑制因子，改变基因组，导致在癌症进程中的细胞重编程。TF的失调与各种癌症类型的发展和维持有关，包括前列腺癌。出现了一组新兴的TF，被认为与肿瘤发生和发展的多个癌症标志物有关。在这里，我们讨论关键TF的作用，这些TF调节了参与前列腺癌发展和进程的转录回路。我们进一步强调与关键癌症标志物相关的TF的作用，包括染色质重塑、基因组不稳定性、DNA修复、侵犯和转移。我们还讨论了TF的多潜能功能，使其具有赋予细胞系可塑性的作用，有助于疾病进展到神经内分泌前列腺癌。最后，我们总结了当前了解和用于治疗靶向TF及其共因子在临床环境中预防疾病进展的方法。Copyright © 2023 Elsevier Ltd. All rights reserved.

Transcription factors (TFs) represent the most commonly deregulated DNA-binding class of proteins associated with multiple human cancers. They can act as transcriptional activators or repressors that rewire the cistrome, resulting in cellular reprogramming during cancer progression. Deregulation of TFs is associated with the onset and maintenance of various cancer types including prostate cancer. An emerging subset of TFs has been implicated in the regulation of multiple cancer hallmarks during tumorigenesis. Here, we discuss the role of key TFs which modulate transcriptional cicuitries involved in the development and progression of prostate cancer. We further highlight the role of TFs associated with key cancer hallmarks, including, chromatin remodeling, genome instability, DNA repair, invasion, and metastasis. We also discuss the pluripotent function of TFs in conferring lineage plasticity, that aids in disease progression to neuroendocrine prostate cancer. At the end, we summarize the current understanding and approaches employed for the therapeutic targeting of TFs and their cofactors in the clinical setups to prevent disease progression.Copyright © 2023 Elsevier Ltd. All rights reserved.