我们的研究旨在评估哪些因素可能影响在我们中心接受内镜下鼻窦肿瘤手术（EOSS）治疗的成人患者的生活质量（QoL）及其随时间的波动，这些患者患有鼻窦恶性肿瘤（SNM）。我们分析了2015年1月至2020年6月期间进行的原发性SNM的EOSS病例。对于每位患者，我们记录了治疗时的年龄、性别、吸烟习惯、使用用于情绪障碍的心境药物、疾病分期、组织学分型、手术切除类型、需要颅底重建、术后重大并发症发生情况以及放疗后的使用情况。我们使用ECOG评分表评估治疗前患者的表现状态。采用三个问卷（SNOT-22; ASK-9; EORTC QLQ-C30）测量生活质量。我们共纳入了55名患者，其中32人（58.18%）接受了放疗。总体而言，在18个月时观察到了所有生活质量指标的显着改善，而女性、较高的ECOG评分、疾病晚期和放射治疗后遭遇的不良反应与较差的生活质量有关。在18个月后，女性与男性在SNOT-22和EORTC QLQ-GLOBAL的生活质量差距加剧，但如果只考虑ECOG中最脆弱的患者，则这种差异在两个工具中都减小了。我们的分析显示，放疗是对患者生活质量影响最大的因素，与女性、ECOG评分> 2和疾病晚期有关。

The aim of our study is to assess which factors may affect the quality of life (QoL) and its fluctuation over time in adult patients who received endonasal endoscopic oncologic sinus surgery (EOSS) for sinonasal malignancies (SNM) in our center.We analyzed EOSS cases for primary SNM from January 2015 to June 2020. For each patient, we have recorded the age at treatment, gender, smoking habits, use of psychotropic drugs for mood disorders, stage, histotype, type of surgical resection, need for skull-base reconstruction, development of postoperative major complications, and the use of adjuvant intensity-modulated radiotherapy (IMRT). We evaluated the patient's performance status pre-treatment using the ECOG scale. Quality of life was measured using three questionnaires (SNOT-22; ASK-9; EORTC QLQ-C30 version 3).Fifty-five patients were enrolled in our study, of whom thirty-two (58.18%) received adjuvant IMRT. Overall, a significant improvement in all QoL outcomes was observed at eighteen months, while, female sex, higher ECOG scores, advanced stage of disease, and adjuvant IMRT were associated with worse QoL. After 18 months the delta in QoL between women and men worsened (in SNOT-22 and EORTC QLQ-GLOBAL) while if only the most fragile patients according to ECOG are considered, this difference was reduced for both tools.Our analysis revealed that IMRT is the element that has the greatest impact on patient's quality of life, in association with the female sex, ECOG >2, and advanced stage of the disease.