目前，由于神经组织的复杂性，大脑内的不成形变化具有挑战性，导致治疗协议的效率低下。细胞界面——即血脑屏障（BBB）的存在，限制了多种大分子和治疗剂进入大脑。迄今为止，已经在实验室和体内条件下使用了几种基于纳米技术的平台，以克服BBB的屏障特性。外泌体（Exos）是一种独特的细胞外囊泡，具有特定的负荷，以副旁方式调节细胞生物活动。由于具有独特的物理化学特性和对各种生物流体的易得性，外泌体为药物输送和治疗目的提供了有利的平台。新兴数据表明，外泌体使得选择性物质如生物活性因子和化疗化合物能够穿过血脑屏障进入大脑。除此之外，智能输送方法的应用可以提高输送效率，从而提高治疗效果。在此，我们重点介绍了外泌体在脑肿瘤背景下的应用的最新进展。 版权所有 © 2023 Elsevier B.V.

At the moment, anaplastic changes within the brain are challenging due to the complexity of neural tissue, leading to the inefficiency of therapeutic protocols. The existence of a cellular interface, namely the blood-brain barrier (BBB), restricts the entry of several macromolecules and therapeutic agents into the brain. To date, several nano-based platforms have been used in laboratory settings and in vivo conditions to overcome the barrier properties of BBB. Exosomes (Exos) are one-of-a-kind of extracellular vesicles with specific cargo to modulate cell bioactivities in a paracrine manner. Regarding unique physicochemical properties and easy access to various biofluids, Exos provide a favorable platform for drug delivery and therapeutic purposes. Emerging data have indicated that Exos enable brain penetration of selective cargos such as bioactive factors and chemotherapeutic compounds. Along with these statements, the application of smart delivery approaches can increase delivery efficiency and thus therapeutic outcomes. Here, we highlighted the recent advances in the application of Exos in the context of brain tumors.Copyright © 2023 Elsevier B.V. All rights reserved.