人类ClpP激活因子进化简化的结构见解。
Structural insights into the evolutionary simplification of human ClpP activators.
发表日期：2023 Feb 02
作者：
Lin-Lin Zhou, Cai-Guang Yang
来源：
STRUCTURE
摘要：
在这一期的《结构》杂志中，Mabanglo等人表征了五种称为TRs的ClpP激动剂。共晶结构揭示了比抗癌药物ONC201更强的形状和电荷互补性。这些新化合物具有潜在的治疗兴趣，因为它们增强ClpP蛋白酶活性并对肿瘤细胞生长产生抑制作用。版权所有©2023 Elsevier Ltd.。
In this issue of Structure, Mabanglo et al. characterize five ClpP agonists termed TRs. The co-crystal structures reveal more robust shape and charge complementarities than the anti-cancer agent ONC201. These novel compounds are of potential therapeutic interest because they enhance ClpP proteolytic activity and have an inhibitory effect on tumor cell growth.Copyright © 2023 Elsevier Ltd. All rights reserved.