韩国冷杉叶中的三萜类化合物及其生物活性。
Triterpenoids from the leaves of Abies koreana and their biological activities.
发表日期：2023 Feb 03
作者：
Dong Jun Lee, Seong-Min Hong, Da Hye Yoon, Song Lim Ham, Jonghwan Kim, Sun Yeou Kim, Sang Un Choi, Chung Sub Kim, Kang Ro Lee
来源：
PHYTOCHEMISTRY
摘要：
七种未描述的三萜类化合物，包括abikoranes A-G，以及三种已知的三萜类化合物从云杉（Abies koreana E. H. Wilson）叶中分离出来。通过1D和2D NMR，HRMS，ECD，旋光度和DP4+分析，揭示了这些化合物的结构。其中，abikorane A是Nor-3,4-seco-17,14-friedo-lanostane三萜类化合物的第二个代表。在这些分离物中，一些化合物对四种检测的癌细胞系（A549，SK-OV-3，SK-MEL-2和HCT-116）表现出强烈的细胞毒活性，IC50值为0.89-9.62 μM，并抑制脂多糖刺激下的NO产生，IC50值为11.57-15.16 μM，同时能显著从C6胶质瘤细胞释放神经生长因子（192.54 ± 12.33%）。版权所有© 2023 Elsevier Ltd.
Seven undescribed triterpenoids, abikoranes A-G, along with three known triterpenoids were isolated from the leaves of Abies koreana E. H. Wilson. The structures of compounds were elucidated by 1D and 2D NMR, HRMS, ECD, specific rotation, and DP4+ analysis. Abikorane A represents the second example of nor-3,4-seco-17,14-friedo-lanostane triterpenoid. Among the isolates, some compounds showed strong cytotoxic activities against some of four tested cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-116) with the values of IC50 0.89-9.62 μM, inhibited lipopolysaccharide-stimulated nitric oxide production with IC50 values of 11.57-15.16 μM, and exhibited significant nerve growth factor release effect (192.54 ± 12.33%) from C6 glioma cells.Copyright © 2023 Elsevier Ltd. All rights reserved.