多发性骨髓瘤（MM）是第二常见的血液恶性肿瘤，然而，它仍然是无法治愈的，而且药物抵抗的潜在发病机制和机理仍不清楚。人们广泛认识到骨髓微环境在调节免疫应答、诱导药物抵抗、促进MM肿瘤增殖和侵袭中发挥着至关重要的作用，因此是一个潜在的治疗靶点。在骨髓微环境的髓瘤细胞与成分之间的各种信号循环中，非编码RNA正在成为微环境内细胞间通信的关键调节因子。非编码RNA（如microRNA、长链非编码RNA、环状RNA和PIWI相互作用RNA）与骨髓瘤细胞生长、存活、迁移、侵袭和药物抵抗涉及的许多生物过程有关。本综述总结了非编码RNA在MM骨髓微环境相互作用调节机制方面的最新进展，并探讨了非编码RNA在MM治疗中的潜力。Copyright © 2023 Elsevier B.V.出版。

Multiple myeloma (MM) is the second most common hematological malignancy; however, it remains incurable, and the underlying pathogenesis and mechanisms of drug resistance remain unclear. It is widely recognized that the bone marrow microenvironment plays a crucial role in regulating the immune response, inducing drug resistance, and promoting tumor proliferation and invasion in MM, and thus serves as a potential therapeutic target. Among the various signaling loops between myeloma cells and components of the microenvironment, noncoding RNAs are emerging as crucial regulators of intercellular communication within the microenvironment. Noncoding RNAs, such as microRNAs, long noncoding RNAs, circular RNAs, and PIWI-interacting RNAs, have been associated with numerous biological processes involved in myeloma cell growth, survival, migration, invasion, and drug resistance. This review summarizes recent advances in the regulatory mechanisms of noncoding RNAs involved in the interaction between the MM bone marrow microenvironment and discusses the therapeutic potential of noncoding RNAs in MM.Copyright © 2023. Published by Elsevier B.V.