探索患有重大唾液腺癌(SGC)的患者的先前癌症史对预后的影响。从SEER数据库中确定了有(次级SGC)和没有(单级SGC)先前癌症的SGC患者。使用Cox比例风险回归(CoxPH)模型比较sec-SGC和one-SGC患者的预后。通过性别、先前癌症类型、先前癌症组织学和癌症诊断间隔(CDI)对sec-SGC患者进行亚组分析。建立两个CoxPH模型以区分具有不同预后风险的sec-SGC患者。 总共有9098名SGC患者被纳入。总的来说，sec-SGC患者(调整后的HR [aHR]=1.26，p<0.001)特别是CDI≤5年的患者(aHR=1.47，p<0.001)的总体生存率(OS)比one-SGC患者差。 在亚组分析中，只有先前患有头颈癌，且为女性的sec-SGC患者(aHR=2.38，p=0.005)，CDI≤5年的患者(aHR=1.65，p=0.007)或先前有鳞状细胞癌的患者(aHR=6.52，p<0.001)的OS更差。 我们的模型成功地将所有的sec-SGC患者区分为高，中和低风险组，具有不同的预后。不同先前癌症类型、性别、CDI和先前癌症的组织学的sec-SGC患者的预后有所不同。我们建立的模型可以帮助区分不同风险的sec-SGC患者的预后。 ©2023 Wiley Periodicals LLC.

To explore the prognostic effects of previous cancer history on patients with major salivary gland cancer (SGC).SGC patients with (sec-SGC) and without (one-SGC) a previous cancer from the SEER database were identified. Cox proportional hazards regression (CoxPH) models were used to compare the prognosis between sec-SGC and one-SGC patients. Subgroup analyses for sec-SGC patients by gender, previous cancer types, previous cancer histology, and cancer diagnosis interval (CDI) were performed. Two CoxPH models were constructed to distinguish sec-SGC patients with different prognostic risks.9098 SGC patients were enrolled. Overall, sec-SGC patients (adjusted HR [aHR] = 1.26, p < 0.001), especially those with a CDI ≤ 5 years (aHR = 1.47, p < 0.001), had worse overall survival (OS) than one-SGC patients. In subgroup analysis, only sec-SGC patients with a previous head and neck cancer who were female (aHR = 2.38, p = 0.005), with a CDI ≤ 5 years (aHR = 1.65, p = 0.007) or with a previous squamous cell carcinoma (aHR = 6.52, p < 0.001) had worse OS. Our models successfully differentiated all sec-SGC patients into high-, intermediate- and low-risk groups with different prognosis.Sec-SGC patients with different previous cancer types, gender, CDI and previous cancer histology had varied prognosis. The models we constructed could help differentiate the prognosis of sec-SGC patients with different risks.© 2023 Wiley Periodicals LLC.