口腔癌是一种在口腔发展的癌症，是世界上最致命的恶性肿瘤之一。目前，手术治疗、放射治疗和化疗是最常见的治疗方法。需要更好的治疗和早期检测策略。化学治疗药物由于毒性和针对肿瘤的效果差而经常失败，容易产生失败的高风险。针对肿瘤的活性、被动和免疫定位技术已被设计出来。纳米技术的药物输送系统是目前最好的解决方案，对于精确定位至关重要。纳米颗粒、脂质体、外泌体和环糊精是用于药物传递的纳米载体。纳米技术正在被用于开发新的技术，如肿瘤内注射、微泡介导的超声疗法、光疗和位点特异性输送。本系统综述详细介绍了这些针对肿瘤和基于纳米的药物输送系统，以提高口腔癌患者的健康和生存率。版权所有 © 2023 Elsevier Inc。

Oral cancer is a type of cancer that develops in the mouth and is one of the deadliest malignancies in the world. Currently surgical, radiation therapy, and chemotherapy are most common treatments. Better treatment and early detection strategies are required. Chemotherapeutic drugs fail frequently due to toxicity and poor tumor targeting. There are high chances of failure of chemotherapeutic drugs due to toxicity. Active, passive, and immunity-targeting techniques are devised for tumor-specific activity. Nanotechnology-based drug delivery systems are the best available solution and important for precise targeting. Nanoparticles, liposomes, exosomes, and cyclodextrins are nano-based carriers for drug delivery. Nanotechnology is being used to develop new techniques such as intratumoral injections, microbubble mediated ultrasonic therapy, phototherapies, and site-specific delivery. This systematic review delves into the details of such targeted and nano-based drug delivery systems in order to improve patient health and survival rates in oral cancer.Copyright © 2023 Elsevier Inc. All rights reserved.