视网膜决定基因网络（RDGN）最初是在果蝇眼睛形成中被发现的关键决定因素，现已成为肿瘤发生和进展以及器官发育的重要调节网络。这个网络不仅与肿瘤的恶性生物学行为有关，如增殖和侵袭，而且还调节了多种哺乳动物器官的发育。这个保守网络的三个成员已经被广泛研究，包括DACH、SIX和EYA。失调的RDGN信号与肿瘤的启动和进展有关。近年来，发现这个网络的成员可以作为癌症患者的预后标志物。此外，它们被认为是癌症的潜在治疗靶点。在这里，我们总结了RDGN成员从生物学功能到信号转导的研究进展，特别强调它们对肿瘤的影响。此外，我们还讨论了RDGN成员在器官和组织发育中的作用以及它们与慢性肾脏病和冠心病的发病机制的相关性。通过总结RDGN成员在人类疾病中的作用，我们希望促进对RDGN的未来研究，并为患者提供潜在的治疗策略。© 2023. 作者。

The retinal determinant gene network (RDGN), originally discovered as a critical determinator in Drosophila eye specification, has become an important regulatory network in tumorigenesis and progression, as well as organogenesis. This network is not only associated with malignant biological behaviors of tumors, such as proliferation, and invasion, but also regulates the development of multiple mammalian organs. Three members of this conservative network have been extensively investigated, including DACH, SIX, and EYA. Dysregulated RDGN signaling is associated with the initiation and progression of tumors. In recent years, it has been found that the members of this network can be used as prognostic markers for cancer patients. Moreover, they are considered to be potential therapeutic targets for cancer. Here, we summarize the research progress of RDGN members from biological functions to signaling transduction, especially emphasizing their effects on tumors. Additionally, we discuss the roles of RDGN members in the development of organs and tissue as well as their correlations with the pathogenesis of chronic kidney disease and coronary heart disease. By summarizing the roles of RDGN members in human diseases, we hope to promote future investigations into RDGN and provide potential therapeutic strategies for patients.© 2023. The Author(s).