青少年和年轻成人（AYAs；15-39岁）的肿瘤流行病学是独特的。欧洲医学肿瘤学会/欧洲儿科肿瘤学会（ESMO/SIOPE）AYA工作组旨在描述欧洲和欧盟成员国AYAs的肿瘤负担。我们使用全球癌症观察站可用的数据。我们检索了原始和年龄标准化（世界标准人口）的发病率和死亡率。我们报告了欧洲和28个欧盟成员国的AYA肿瘤负担情况。我们描述了所有癌症和最适合AYA人群的13种癌症的发病率和死亡率。不同国家之间的发病率和死亡率差异很大，东欧国家的死亡率最高。女性乳腺癌、甲状腺癌和男性睾丸癌是各国最常见的癌症，其次是皮肤黑色素瘤和子宫颈癌。不同人群之间癌症发病率的变化可能反映了不同的风险因素分布、筛查实施或接受的差异以及过度诊断。AYA癌症死亡率的差异可能是早期诊断差异、公众教育和癌症症状意识的差异、不同程度的治疗途径或可用性导致。我们的结果凸显了AYA专业服务的未来医疗保健需求和要求，以确保不同国家之间的均匀治疗，以及预防计划的紧迫性，以缓解不断增加的负担。版权所有©2022。由Elsevier Ltd.出版。

Cancer epidemiology is unique in adolescents and young adults (AYAs; aged 15-39 years). The European Society for Medical Oncology/European Society for Paediatric Oncology (ESMO/SIOPE) AYA Working Group aims to describe the burden of cancers in AYAs in Europe and across European Union (EU) countries.We used data available on the Global Cancer Observatory. We retrieved crude and age-standardised (World Standard Population) incidence and mortality rates. We reported about AYA cancer burden in Europe and between 28 EU member states. We described incidence and mortality for all cancers and for the 13 cancers most relevant to the AYA population.Incidence and mortality varied widely between countries with the highest mortality observed in Eastern EU countries. Cancers of the female breast, thyroid and male testis were the most common cancers across countries followed by melanoma of skin and cancers of the cervix. Variations in cancer incidence rates across different populations may reflect different distribution of risk factors, variations in the implementation or uptake of screening as well as overdiagnosis. AYA cancer mortality disparities may be due to variation in early-stage diagnoses, different public education and awareness of cancer symptoms, different degrees of access or availability of treatment.Our results highlight the future health care needs and requirements for AYA-specialised services to ensure a homogeneous treatment across different countries as well as the urgency for preventive initiatives that can mitigate the increasing burden.Copyright © 2022. Published by Elsevier Ltd.