早发性卵巢功能不全（POI）的诊断对许多患者来说是一次创伤性事件，涉及不良的生育预后。在这样的诊断后，自然怀孕的情况很少。建立家庭的替代方案包括卵子捐赠、胚胎捐赠和领养。然而，我们知之甚少，关于有多少患有 POI 的妇女在诊断后最终建立了家庭，以及她们选择了哪种替代方案。我们进行了一项横断面、描述性研究。我们对在蔑庇特-萨尔佩特丽尔内分泌与生殖医学科咨询 POI 的所有妇女进行了调查，时间从 1991 年 5 月 31 日到 2021 年 1 月 12 日。我们包括了在我们科室继续定期随访或在 2021 年 6 月到 9 月期间通过邮件或电话联系的患者。我们排除了在调查时患有 Turner 综合征、因肿瘤治疗导致 POI 的患者以及 18 岁以下的患者。985 名患者被转介到该科室接受 POI 的诊断，最终分析了 324 名患者。想要建立家庭的妇女中，有 41% 在诊断后生育了孩子：53.9% 通过卵子捐赠、1 名女性通过胚胎捐赠、5.6% 通过卵巢刺激后怀孕、13.5% 进行了领养，而 25.8% 在平均 2.5 年后自然怀孕。整个队列的自然怀孕率为 8.6%。诊断 POI 后生育孩子并不罕见，但更常见的是通过卵子捐赠实现的。这项研究将为新诊断的妇女提供智慧信息，以了解在 POI 诊断后建立家庭的可能性。© 2023 年作者。牛津大学出版社代表 (ESE) 欧洲内分泌学会出版。

The diagnosis of premature ovarian insufficiency (POI) is a traumatic event for many patients that involves poor fertility prognosis. After such diagnosis spontaneous pregnancies are rare. The alternatives for building a family are oocyte donation, embryo donation and adoption. However, we have few information on how many women with POI finally built a family after the diagnosis and which alternative they chose.We performed a cross-sectional, descriptive study.We conducted a survey of all the women who consulted for POI in the department of endocrinology and reproductive medicine at la Pitié Salpêtrière between 31/05/1991 and 12/01/2021. We included patients who continued to be followed up regularly by our department or were contacted by mail or phone between June and September 2021. We excluded patients with Turner syndrome, POI secondary to oncological treatment and patients under 18 at the time of the survey.985 patients were referred to the department for POI and 324 patients were finally analysed. 41% of the women who wanted to build a family had children after the diagnosis: 53,9% by oocyte donation 1 woman by embryo donation, 5,6% after ovarian stimulation, 13,5% adopted and 25,8% had spontaneous pregnancy after a mean time of 2,5 years. Spontaneous pregnancy rate was 8,6% in the whole cohort.Having children after a diagnosis of POI is not uncommon, but more often results from oocyte donation. This study will provide enlightened information for newly diagnosed women on the possibilities to build a family after POI diagnosis.© The Author(s) 2023. Published by Oxford University Press on behalf of (ESE) European Society of Endocrinology.