高危粘膜型人乳头瘤病毒（HR-HPV）似乎在皮肤鳞状细胞癌（cSCC）中起着一定的作用，尤其是在指甲肿瘤中，其中已经有人提出了生殖周数传播的假设。需要澄清HR-HPV在手指非指甲cSCC中的作用。为了评估HR-HPV在手指cSCC中的流行率、临床病理学特征、替代指标和结局。这是一项观察性双中心研究，包括患有位于手指上的原位或侵袭性cSCC的患者。评估了HR-HPV和非HR-HPV肿瘤之间的差异。共计45位患者（45个肿瘤）被纳入研究。在这些患者中，33%的病例检测到了HR-HPV（其中22%为HPV类型16）。HR-HPV患者的平均年龄较低，低于非HR-HPV患者（62.4岁 vs. 81.1岁，P=0.001）。HR-HPV肿瘤较小（10毫米 vs. 15毫米，P=0.07），更频繁地表现为皮内型（60% vs. 20%，P=0.004）。弹性纤维缺失（P=0.030）和炎症缺失（P=0.026），以及基底细胞样形态（P=0.003）是HR-HPV检测的代用品。HR-HPV肿瘤的p16阳性率平均为61%，而非HR-HPV肿瘤的p16阳性率为36%（P=0.061）。手术后的复发在HR-HPV肿瘤中较常见（58% vs. 34%），尽管这并没有统计学意义。在非指甲的肿瘤中，检测到了27%的HR-HPV。与非HR-HPV肿瘤相比，与HR-HPV相关的手指cSCC出现在年龄较轻的患者身上，肿瘤较小且渗透性较少。基底样形态的存在以及弹性纤维和炎症的缺失可用作HR-HPV检测的标志。在非指甲的cSCC中，HR-HPV的高流行率表明其在这些肿瘤的发病和病理机制中起着作用。©2022年作者。由牛津大学出版社代表英国皮肤科医师协会出版。保留所有权利。有关权限，请发送电子邮件至：journals.permissions@oup.com。

High-risk mucosal human papillomavirus (HR-HPV) seems to play a role in cutaneous squamous cell carcinoma (cSCC), particularly in nail tumours, where genitodigital transmission has been suggested. The role of HR-HPV in nonungual cSCC of the finger needs to be clarified.To evaluate the prevalence, clinicopathological characteristics, surrogates and outcomes of HR-HPV in cSCC of the finger.This was an observational bicentric study including patients with an excised in situ or invasive cSCC located on the finger. Differences in HR-HPV and non-HR-HPV tumours were evaluated.Forty-five patients (45 tumours) were included. HR-HPV was detected in 33% of cases (22% HPV type 16). The mean age was lower in patients with HR-HPV than in those with non-HR-HPV (62·4 vs. 81·1 years, P = 0·001). HR-HPV tumours were smaller (10 mm vs. 15 mm, P = 0·07) and more frequently intraepidermal (60% vs. 20%, P = 0·004). The absence of elastosis (P = 0·030) and inflammation (P = 0·026) and the presence of basaloid morphology (P = 0·003) were surrogates of HR-HPV detection. Mean p16 positivity was 61% in HR-HPV and 36% in non-HR-HPV tumours (P = 0·061). Recurrence after surgery was more common in HR-HPV tumours (58% vs. 34%), although this was not statistically significant. HR-HPV was detected in 27% of the nonungual tumours.HR-HPV-associated cSCC of the finger appears in younger patients, is smaller and is less infiltrative than non-HR-HPV tumours. The presence of a basaloid morphology and the absence of elastosis and inflammation could be used as markers for HR-HPV detection. The high prevalence of HR-HPV in nonungual cSCC suggests its aetiopathogenic role in these tumours.© The Author(s) 2022. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.