Paradoxical cancer cell stimulation by IFNγ drives tumor hyperprogression upon checkpoint blockade immunotherapy. IFNγ的悖论性癌细胞刺激促进了免疫检查点阻断治疗后的肿瘤超级进展。
Paradoxical cancer cell stimulation by IFNγ drives tumor hyperprogression upon checkpoint blockade immunotherapy.
发表日期：2023 Feb 13
作者：
Stephane Champiat, Aurelien Marabelle
来源：
CANCER CELL
摘要：
超级快速进展是在免疫疗法中少数患者中观察到的一种矛盾的癌症加速现象。在本期《癌细胞》杂志上，李等证明了超级快速进展的肿瘤上调了Wnt/β-catenin通路。这种激活是由IFNγ释放的CD8+ T细胞在PD-1/PD-L1阻断后产生的肿瘤源性FGF2介导的自分泌环路所致。版权所有©2023 Elsevier Inc.。保留所有权利。
Hyperprogression is a paradoxical cancer acceleration observed in a minority of patients upon immunotherapy. In this issue of Cancer Cell, Li et al demonstrate that hyperprogressive tumors upregulate the Wnt/β-catenin pathway. This activation was subsequent to an oncogenic FGF2-mediated autocrine loop generated by the IFNγ released by CD8+ T cells upon PD-1/PD-L1 blockade.Copyright © 2023 Elsevier Inc. All rights reserved.