NKG2A阻止了自然杀伤细胞的抗转移功能。
NKG2A blocks the anti-metastatic functions of natural killer cells.
发表日期：2023 Feb 13
作者：
Florent Carrette, Eric Vivier
来源：
CANCER CELL
摘要：
胰腺导管腺癌（PDAC）来源的肝转移是一个重要的未满足的医疗需求。刘等人表明，来自肝门静脉（HPV）而不是原发或转移部位的循环肿瘤细胞（CTCs），通过NKG2A/HLA-E轴被自然杀伤细胞（NK细胞）保护。干扰该途径可释放NK细胞并防止PDAC转移。©2023 Elsevier Inc.版权所有。
Pancreatic ductal adenocarcinoma (PDAC)-derived liver metastasis represents a major unmet medical need. Liu et al. show that circulating tumor cells (CTCs) from the hepatic portal vein (HPV), and not from primary or metastatic sites, are protected from natural killer (NK) cells through the NKG2A/HLA-E axis. Interfering with this pathway unleashes NK cells and prevents PDAC metastasis.Copyright © 2023 Elsevier Inc. All rights reserved.