研究动态
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儿科移植物抗宿主病(GVHD)诊所口腔并发症的回顾性研究。

Oral complications in a paediatric graft versus host disease (GVHD) clinic: a retrospective study.

发表日期:2023 Feb 14
作者: Chitra Priya Emperumal, Brett Weller, Sara Okane, Renita Joseph, Sandhya Kharbanda, Zhan Ling, Alessandro Villa
来源: ORAL DISEASES

摘要:

本研究目的在于调查加利福尼亚大学旧金山分校(UCSF)一家多学科移植物抗宿主病(GVHD)儿科诊所就诊的异基因移植受者的口腔健康状况。这是一项回顾性队列研究,研究对象为2010年1月至2021年9月间在移植物抗宿主病儿科诊所接受异基因移植的患者。通过描述性统计学对人口统计、医疗和口腔健康数据进行记录和分析。 共有25名就诊于儿科移植物抗宿主病诊所的患者(男性占68%),移植时中位数年龄为12岁。其中,12名患者(48%)被诊断出患有口腔慢性GVHD,11名(44%)出现口干症状,4名(16%)出现口腔假膜性念珠菌病,1名(4%)出现复发性单纯疱疹病毒(HSV)感染,1名(4%)出现哺乳动物雷帕霉素抑制剂口炎,并由口腔医学团队根据需要使用药物进行治疗,如局部类固醇(44%)和抗真菌药物(20%)。 造血干细胞移植接受者可能出现各种口腔并发症。多学科团队的医疗模式,包括口腔专家在内,可能会使患者受益。本文受版权保护。版权所有。
The aim of this study was to investigate the oral health status among allogeneic transplant recipients who were seen in a multidisciplinary graft-versus-host disease paediatric clinic at the University of California, San Francisco (UCSF).This was a retrospective cohort study of patients who underwent allogeneic transplants and were seen in the graft-versus-host disease paediatric clinic between January 2010 and September 2021. Demographic, medical and oral health data were recorded and analysed using descriptive statistics.A total of 25 patients were seen in the paediatric graft-versus-host disease clinic (68% males) with a median age of 12 years at the time of transplant were included. Among them, 12 patients (48%) were diagnosed with oral chronic GVHD, 11 (44%) with dry mouth, four (16%) with oral pseudomembranous candidiasis, one (4%) with recrudescent Herpes Simplex Virus (HSV) infection and one (4%) with mammalian target of rapamycin-inhibitor stomatitis and were managed by the oral medicine team, accordingly with medications, such as topical steroids (44%) and anti-fungal (20%).HSCT recipients may present with a variety of oral complications. Patients may benefit by a multi-disciplinary approach including a dental specialist as part of the cancer care team.This article is protected by copyright. All rights reserved.