严重症状缓解治疗在脑胶质母细胞瘤患者中历史上一直被低估。此外，在脑胶质母细胞瘤晚期的医疗保健利用和生命维持措施方面的文献也有限。本研究旨在通过回顾性分析台湾癌症登记处于2007年1月至2017年12月之间的患者，比较接受严重症状缓解治疗和未接受缓解治疗的脑胶质母细胞瘤患者之间的医疗保健和生命维持措施利用情况。本研究中，缓解护理的定义基于提交给全民健康保险机构的索赔，该机构有一个特定的编码。变量包括人口特征、医疗保健服务利用和侵入性生命维持措施。在识别的1994名脑胶质母细胞瘤患者中，有1784名符合纳入标准，其中613名（34％）接受了严重症状缓解治疗。接受缓解治疗的脑胶质母细胞瘤患者的生存期显著长于未接受缓解治疗的患者。未接受缓解治疗的患者住进重症监护病房的频率更高，重症监护病房累积住院时间更长。关于心肺或呼吸治疗，未接受缓解治疗的患者比接受缓解治疗的患者进行更多的侵入性治疗。接受缓解治疗的患者比未接受生命维持措施的患者的风险明显更低。我们的回顾性分析显示，在死亡前一年，未接受严重症状缓解治疗的脑胶质母细胞瘤患者有更大的机会接受生命维持措施，尽管与接受缓解治疗的患者相比没有生存上的好处。这些发现强调了为脑胶质母细胞瘤患者提供严重症状缓解治疗的紧迫性。

Palliative care has historically been under-utilized in patients with glioblastoma. Furthermore, literature on the utilization of healthcare and life-sustaining interventions during the late-stage of glioblastoma has been limited.To identify and compare healthcare utilization and life-sustaining interventions between patients with glioblastoma who received palliative care and who did not based on patients identified retrospectively from Taiwan Cancer Registry between January 2007 and December 2017.In this study, palliative care was defined on the basis of claims submitted to the National Health Insurance, which has a specific code for it. Variables included demographic characteristics, the utilization of healthcare services, and invasive life-sustaining interventions.Of the 1994 patients with glioblastoma identified, 1784 fulfilled the inclusion criteria, 613 (34%) of whom received palliative care.The survival of patients with glioblastoma under palliative care was significantly longer than that of those without palliative care. Those without palliative care had significantly more frequent intensive care unit admissions and a longer cumulative length of intensive care unit stay. Regarding cardiopulmonary or respiratory treatments, patients without palliative care had significantly more invasive interventions than those with palliative care. Patients receiving palliative care had significantly lower odds than those without life-sustaining interventions.Our retrospective analysis reveals that glioblastoma patients without palliative care had greater odds of receiving life-sustaining treatments within 1 year before their death, although no gains in survival as compared to those that received palliative care. These findings highlight the urgent need for palliative care in caring for patients with glioblastoma.