分析和总结恶性舌下腺肿瘤（MSLGT）的临床病理特征，颈淋巴转移的危险因素和预后因素。回顾性地收集2005年1月至2017年12月在上海九院诊断为MSLGT的患者。总结临床病理特征，并使用卡方检验评估临床病理参数、颈淋巴转移和局部复发之间的相关性。采用Kaplan-Meier方法和Cox回归分析评估存活率和独立预后因素。共纳入79例患者，5年总生存率和无病生存率分别为85.7％和71.7％。性别和临床肿瘤分期是颈淋巴转移的危险因素。肿瘤大小和病理淋巴结（LN）分期是舌下腺腺样囊性癌（ACC）的独立预后因素；而年龄、病理LN分期和远处转移是非ACC舌下腺肿瘤患者的预后因素。临床分期较高的患者更容易出现肿瘤复发。恶性舌下腺肿瘤是罕见的疾病，在男性MSLGT患者中应进行颈部淋巴结清扫。在ACC和非ACC MSLGT患者中，pN+提示预后不良。本文受版权保护。保留所有权利。

To analyze and summarize the clinicopathological features, risk factors for cervical nodal metastasis, and prognostic factors of malignant sublingual gland tumors (MSLGT).Patients diagnosed with MSLGT were retrospectively reviewed from January 2005 to December 2017 at Shanghai Ninth Hospital. The clinicopathological features were summarized, and the correlations between clinicopathological parameters, cervical nodal metastasis, and local-regional recurrence were evaluated using the Chi-squared test. Kaplan-Meier method and Cox regression analysis were performed to assess the survival and independent prognostic factors.Seventy-nine patients were included, and the 5-year overall survival and disease-free survival rates was 85.7% and 71.7%, respectively. Gender and clinical tumor stage were risk factors for cervical nodal metastasis. Tumor size and pathological lymph node (LN) stage were independent prognostic factors for adenoid cystic carcinoma (ACC) of the sublingual gland; while age, pathological LN stage, and distant metastasis were prognostic factors for patients with non-ACC of the sublingual gland. Patients with higher clinical stage were more likely to undergo tumor recurrence.Malignant sublingual gland tumors are rare, and neck dissection should be performed in male MSLGT patients with higher clinical stage. Among patients with both ACC and non-ACC MSLGT patients, pN+ indicate a poor prognosis.This article is protected by copyright. All rights reserved.