评估颅咽管瘤患者（颅底肿瘤会影响睡眠-清醒系统）的睡眠情况、疲劳和过度需要睡眠。回顾性研究观察所有成人颅咽管瘤患者前往睡眠诊所的情况，进行睡眠调查、夜间多项睡眠检查、多次睡眠潜伏期测试（MSLT）和18小时卧床多项睡眠检查。将睡眠测量结果与年龄和性别匹配的健康对照组进行比较。筛选54例颅咽管瘤患者中，分析42例，其中80%抱怨白天过度嗜睡。睡眠测试显示，在这6例患者中有二次性嗜睡（包括一例猫病），11例有医学相关的中枢型嗜睡。与对照组相比，患者更容易肥胖，MSLT测量结果和第一晚睡眠时间更短。有一个趋势表明，患有嗜睡症和嗜睡症综合征的患者与其他患者相比更年轻，具有更高的体重指数，更有可能接受放疗，手术后下丘脑受损更严重。兴奋剂治疗（莫达非尼、皮托利生和哌醇）对10例患者中有9例有帮助。近半数患有颅咽管瘤和睡眠障碍的患者有中枢过度嗜睡症（嗜睡病和嗜睡症），应予以调查，并考虑除了睡眠呼吸暂停综合征外的其他疾病。©2023作者发表。由牛津大学出版社代表睡眠研究学会发布。版权所有。请邮件询问授权：journals.permissions@oup.com。

To evaluate sleep, sleepiness and excessive need for sleep in patients with craniopharyngioma (a suprasellar tumor which can affect sleep-wake systems).A retrospective study of all adult craniopharyngioma patients referred to the sleep clinic, who received a sleep interview, nocturnal polysomnography, multiple sleep latency tests (MSLT) and 18-hour bed rest polysomnography. Their sleep measurements were compared with those of age- and sex-matched healthy controls.Of 54 patients screened with craniopharyngioma, 42 were analyzed, 80% of whom complained of excessive daytime sleepiness. Sleep testing revealed that 6 (14.3%) of them had secondary narcolepsy (including one with cataplexy), and 11 (26.2%) had central hypersomnia associated with a medical disorder. Compared with controls, patients were more frequently obese, had a shorter mean sleep latency on MSLT and slept longer on the first night. There was a non-significant trend for patients with (vs. without) narcolepsy and hypersomnia to be younger, to have a higher body mass index, to be more likely to have received radiation therapy and to have more severe damage to the hypothalamus after surgery. Treatment with stimulants (modafinil, pitolisant and methylphenidate) was beneficial in 9/10 patients.Nearly half of the patients with craniopharyngioma and sleep disorders have a central disorder of hypersomnolence (narcolepsy and hypersomnia), which should be investigated and lead to considerations beyond sleep apnea syndrome in these obese patients.© The Author(s) 2023. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.