为比较68 Ga-FAPI-04 PET/CT和18 F-FDG PET/CT在检测胃、十二指肠和结肠癌复发、淋巴结和远处转移的潜在疗效，进行了该单中心回顾性临床研究。该研究于2020年1月至2022年6月在西南医科大学附属医院进行。胃、十二指肠和结肠癌根治切除后的参与者均接受了68 Ga-FAPI-04和18 F-FDG PET/CT检查，参考标准为组织病理学检查、形态学影像学和/或随访影像学。使用配对样本t检验比较了18 F-FDG和68 Ga-FAPI-04 PET/CT检测的最大标准摄取值与肿瘤复发、淋巴结和远处转移之间的差异。 共纳入了41名年龄中位数为51岁（范围19-75岁）的胃、十二指肠和结肠癌患者。与18 F-FDG PET/CT相比，68 Ga-FAPI-04 PET/CT检测肿瘤复发（6/6 [100%] vs. 4/6 [67%]）、淋巴结转移（92/92 [100%] vs. 31/92 [34%]）和远处转移（28/30 [93%] vs. 20/30 [67%]）的敏感性更高。 因此，68 Ga-FAPI-04 PET/CT在胃、十二指肠和结肠癌的再评估中表现出更高的准确性，有助于改善治疗决策。知识产权归沃尔特斯·克鲁尔健康公司所有，未经许可，不得复制。

To compare the potential efficacy of 68 Ga-FAPI-04 PET/CT with that of 18 F-FDG PET/CT for detecting tumor recurrence and nodal and distant metastases in gastric, duodenal, and colorectal cancers.This single-center retrospective clinical study was performed at the Affiliated Hospital of Southwest Medical University between January 2020 and June 2022. Participants with gastric, duodenal, and colorectal cancers after curative resection underwent both 68 Ga-FAPI-04 and 18 F-FDG PET/CT. Histopathologic examination, morphologic imaging, and/or follow-up imaging served as the reference standards. The SUV max of the tumor recurrence and nodal and distant metastases between 18 F-FDG and 68 Ga-FAPI-04 PET/CT were compared using the paired-sample t test.Forty-one participants with gastric, duodenal, and colorectal cancers were enrolled in the study (median age, 51 years; range, 19-75 years). The sensitivity of 68 Ga-FAPI-04 PET/CT was higher than that of 18 F-FDG PET/CT for detecting tumor recurrence (6 of 6 [100%] vs 4 of 6 [67%]), nodal metastases (92 of 92 [100%] vs 31 of 92 [34%]), and distant metastases (28 of 30 [93%] vs 20 of 30 [67%]).68 Ga-FAPI-04 PET/CT for tumor re-evaluation showed potential for more accurate performance of gastric, duodenal, and colorectal cancers, thereby improving treatment decision-making.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.