为了提高升压酚（HNK）对乳腺癌的抗转移效果，我们设计了阳离子脂质体（Lip），将HNK封装到Lip中，并用带负电的多聚神经酰胺酸（PSA-Lip-HNK）修饰其表面，以有效治疗乳腺癌。 PSA-Lip-HNK具有均匀的球形和高的封装效率。体外4T1细胞实验表明，PSA-Lip-HNK通过由PSA和选择素受体介导的内吞作用途径增加了细胞摄取和细胞毒性。此外，通过创口愈合和细胞运动和侵袭，PSA-Lip-HNK的显著抗肿瘤转移影响得到了确认。通过活体荧光成像，在4T1肿瘤携带小鼠中观察到PSA-Lip-HNK的增强体内肿瘤积累。对于使用4T1肿瘤携带的小鼠进行体内抗肿瘤实验，PSA-Lip-HNK表现出更高的肿瘤生长和转移抑制，与未修改的脂质体相比。因此，我们相信PSA-Lip-HNK很好地结合了生物相容性PSA纳米递送和化疗，为转移性乳腺癌治疗提供了一种有前途的药物递送方法。

To improve the anti-metastasis effects of honokiol (HNK) on breast cancer, we designed cationic liposomes (Lip) in which HNK was encapsulated into Lip, and its surface was modified with negatively charged polysialic acid (PSA-Lip-HNK) for efficient treatment of breast cancer. PSA-Lip-HNK possessed a homogeneous spherical shape and high encapsulation efficiency. In vitro 4T1 cell experiments indicated that PSA-Lip-HNK increased cellular uptake and cytotoxicity via the endocytosis pathway mediated by PSA and selectin receptors. Furthermore, the significant antitumor metastasis impact of PSA-Lip-HNK was confirmed by wound healing and cell migration and invasion. Enhanced in vivo tumor accumulation of the PSA-Lip-HNK was observed in 4T1 tumor-bearing mice by living fluorescence imaging. For in vivo antitumor experiments using 4T1 tumor-bearing mice, PSA-Lip-HNK exhibited a higher tumor growth and metastasis inhibition compared with unmodified liposomes. Therefore, we believe that PSA-Lip-HNK well combined biocompatible PSA nano-delivery and chemotherapy, providing a promising drug delivery approach for metastatic breast cancer therapy.