Mohs微创手术（MMS）是高危基底细胞癌（BCC）的首选治疗方法。然而，目前尚无基于证据的建议，关于在进行MMS之前，哪种活检技术最适合获取肿瘤样本。根据肿瘤的临床特征、外科医生经验和当地规定，可以使用刮取或冲压活检。然而，活检类型可能导致难以进行组织病理学解释，并影响MMS的实际实施。我们对208例连续接受MMS治疗的BCC进行了回顾性研究。其中42例（20.2％）通过刮取方法获得活检，166例（79.8％）通过冲压方法获得活检。通过刮取技术获得的肿瘤，平均有1.64个时期，而通过冲压技术获得的肿瘤平均有1.69个时期（p值=0.130）。这些发现表明活检类型不会影响Mohs手术的执行。最佳的活检类型是针对每个具体病例确定合适的，以获取诊断和肿瘤分型。© 作者（2023）。由英国皮肤科医师协会的牛津大学出版社发表。保留所有权利。有关权限，请发送电子邮件至：journals.permissions@oup.com。

Mohs micrographic surgery (MMS) is the treatment of choice for high-risk basal cell carcinoma (BCC). However, there are no evidence-based recommendations regarding which biopsy technique is the most appropriate to obtain tumour samples prior to MMS. Shave or punch biopsies are performed depending on the clinical characteristics of the tumour, surgeon experience, and local protocols. However, biopsy type might result in difficult histopathological interpretation and influence the practical implementation of MMS. We performed a retrospective study on 208 consecutive BCC treated with MMS. 42 (20.2%) biopsies were obtained by the shave method and 166 (79.8%) via punch. Those obtained with the shave technique had a mean of 1.64 stages vs 1.69 stages with the punch technique (p-value=0.130). These findings suggest biopsy type does not affect Mohs surgery performance. The best biopsy type is the one deemed adequate for each specific case to obtain a diagnosis and tumour subtyping.© The Author(s) 2023. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.