对人类来说，急性和慢性过量接触紫外线（UV）辐射会导致组织损伤，例如晒伤，并促进癌症的发展。UV辐射的免疫调节特性和相关的健康后果我们还不太了解。在此，我们使用蜡蛾Galleria mellonella的幼虫，来确定UV驱动下与先天免疫细胞组分相关的变化。从免疫细胞（血细胞）的反应和抗微生物因子的产生来看，这些昆虫与哺乳动物细胞的先天免疫有许多功能相似之处。在将昆虫暴露于UVA或UVB长达两小时后，我们监测了幼虫的存活率、感染敏感性、血淋巴（血液）生理和粪便排泄。将幼虫长时间暴露于UVB辐射，可引起存活率减少、对细菌挑战敏感性增强、血淋巴中黑色素的合成、血细胞的功能受损和排泄物（细菌）内容的改变。我们认为G. mellonella是一种可靠的体内模型，用于评估紫外线暴露对整个有机体和细胞层面的影响。Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

For humans, acute and chronic overexposure to ultraviolet (UV) radiation can cause tissue damage in the form of sunburn and promote cancer(s). The immune-modulating properties of UV radiation and health-related consequences are not well known. Herein, we used the larvae of the wax moth Galleria mellonella, to determine UV-driven changes in cellular components of innate immunity. From immune cell (haemocyte) reactivity and the production of antimicrobial factors, these insects share many functional similarities with mammalian cellular innate immunity. After exposing insects to UVA or UVB for up to two hours, we monitored larval viability, susceptibility to infection, haemolymph (blood) physiology and faecal discharge. Prolonged exposure of larvae to UVB coincided with decreased survival, enhanced susceptibility to bacterial challenge, melanin synthesis in the haemolymph, compromised haemocyte functionality and changes in faecal (bacterial) content. We contend G. mellonella is a reliable in vivo model for assessing the impact of UV exposure at the whole organism and cellular levels.Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.