碳酸氢盐转运作为胰腺癌抗肿瘤免疫的调节因子。
Bicarbonate transport as regulator of anti-tumour immunity in pancreatic cancer.
发表日期：2023 Feb 21
作者：
Emily J Kay, Sara Zanivan
来源：
Molecular Oncology
摘要：
碳酸氢盐转运是胰腺导管细胞pH调节的预先存在的机制。在最近的一项研究中，Cappellesso等人证明，胰腺导管癌代谢重构会产生酸性环境，并通过SLC4A4将碳酸氢盐导入癌细胞，增强该环境的酸度。这种酸度有利于促进肿瘤免疫抑制。靶向SLC4A4能够中和环境pH值，恢复抗肿瘤免疫力，使肿瘤对免疫检查点阻滞敏感。本文受版权保护，所有权利均已保留。
Bicarbonate transport is a pre-existing mechanism of pH regulation in pancreatic ductal cells. In a recent study, Cappellesso et al. demonstrated that pancreatic ductal adenocarcinoma metabolic rewiring creates an acidic environment, enhanced by bicarbonate import into cancer cells via SLC4A4. This acidity favours pro-tumourigenic immunosuppression. Targeting SLC4A4 neutralises environmental pH and restores anti-tumour immunity, sensitising tumours to immune checkpoint blockade.This article is protected by copyright. All rights reserved.