童年癌症成人幼年癌症幸存者不太遵循营养指南，饮食中维生素D、E、钾、纤维素、镁和钙的摄入量不足。维生素和矿物质补充剂在总营养素摄入中的贡献在这个群体中尚不清楚。我们调查了参加圣·裘德终身队列研究的2570名幼年癌症成人幸存者的营养素摄入率和剂量，以及饮食补充剂使用与治疗暴露、症状负担和生活质量的关联。近40％的成年癌症幸存者报告定期使用膳食补充剂。尽管使用膳食补充剂的癌症幸存者较少缺乏一些营养素，但其过量摄入（总营养素摄入量≥可承受的上限）的叶酸（15.4％vs.1.3％）、维生素A（12.2％vs.0.2％）、铁（27.8％vs.1.2％）、锌（18.6％vs.1％）和钙（5.1％vs）1％）与没有使用膳食补充剂的幸存者相比（所有p<0.05）。治疗暴露、症状负担和身体功能与补充剂使用不相关，而情感幸福感和活力与幼年癌症幸存者的补品使用呈正相关。膳食补充剂的使用既与某些营养素的摄入不足又与其过量摄入有关，但对幼年癌症幸存者的生活质量方面有积极影响。©2023美国癌症协会。

Adult survivors of childhood cancer have poor adherence to nutrition guidelines and inadequate intake of dietary vitamins D and E, potassium, fiber, magnesium, and calcium. The contribution of vitamin and mineral supplement use to total nutrient intake in this population is unclear.We examined the prevalence and dose of nutrient intake among 2570 adult survivors of childhood cancer participating in the St. Jude Lifetime Cohort Study, and the association of dietary supplement use with treatment exposures, symptom burden, and quality of life.Nearly 40% of the adult survivors of cancer survivors reported regular use of dietary supplements. Although cancer survivors who used dietary supplements were less likely to have inadequate intake of several nutrients, they were also more likely to have excessive intake (total nutrient intake ≥ tolerable upper intake levels) of folate (15.4% vs. 1.3%), vitamin A (12.2% vs. 0.2%), iron (27.8% vs. 1.2%), zinc (18.6% vs. 1%), and calcium (5.1% vs. 0.9%) compared with survivors who did not use dietary supplements (all p < 0.05). Treatment exposures, symptom burden, and physical functioning were not associated with supplement use, whereas emotional well-being and vitality were positively associated with supplement use among childhood cancer survivors.Supplement use is associated with both inadequate and excessive intake of specific nutrients, but positively impacts aspects of quality of life among childhood cancer survivors.© 2023 American Cancer Society.