化学动力疗法（CDT）是一种使用费托催化剂将内源性过氧化氢（H2O2）转化为羟基自由基(·OH)的治疗癌症的有前途的策略，然而，内源性H2O2和谷胱甘肽（GSH）过量表达不足以使其效率令人满意。在此，我们介绍一种智能纳米催化剂，它由铜过氧化物纳米点和DOX-载有介孔二氧化硅纳米粒子（MSNs）（DOX@MSN@CuO2）组成，可以自我补充外源性H2O2并响应特定的肿瘤微环境（TME）。在被内吞到肿瘤细胞后，DOX@MSN@CuO2最初分解成Cu2+和外源性H2O2在弱酸性的TME中生成。随后，Cu2+与高浓度的GSH反应，引起GSH耗竭并将Cu2+还原为Cu+。接下来，生成的Cu+与外源性H2O2发生费托样反应，以加速毒性·OH的产生，该物质表现出快速的反应速率，并负责肿瘤细胞凋亡，从而增强CDT的效果。此外，DOX从MSNs中成功传递，实现了化疗和CDT的整合。因此，这种优秀的策略可以解决由于有限的H2O2和GSH过表达而导致CDT疗效不足的问题。整合H2O2的自我补给和GSH消除增强CDT，并且DOX引起的化疗使DOX@MSN@CuO2在体内具有有效的抑制肿瘤生长的特性，并且副作用最小。

Chemodynamic therapy (CDT) that involves the use of Fenton catalysts to convert endogenous hydrogen peroxide (H2O2) to hydroxyl radicals (·OH) constitutes a promising strategy for cancer therapy; however, insufficient endogenous H2O2 and glutathione (GSH) overexpression render its efficiency unsatisfactory. Herein, we present an intelligent nanocatalyst that comprises copper peroxide nanodots and DOX-loaded mesoporous silica nanoparticles (MSNs) (DOX@MSN@CuO2) and can self-supply exogenous H2O2 and respond to specific tumor microenvironments (TME). Following endocytosis into tumor cells, DOX@MSN@CuO2 initially decomposes into Cu2+ and exogenous H2O2 in the weakly acidic TME. Subsequently, Cu2+ reacts with high GSH concentrations, thereby inducing GSH depletion and reducing Cu2+ to Cu+ Next, the generated Cu+ undergoes Fenton-like reactions with exogenous H2O2 to accelerate toxic ·OH production, which exhibits a rapid reaction rate and is responsible for tumor cell apoptosis, thereby enhancing CDT. Furthermore, the successful delivery of DOX from the MSNs achieves chemotherapy and CDT integration. Thus, this excellent strategy can resolve the problem of insufficient CDT efficacy due to limited H2O2 and GSH overexpression. Integrating H2O2 self-supply and GSH deletion enhances CDT, and DOX-induced chemotherapy endows DOX@MSN@CuO2 with effective tumor growth-inhibiting properties alongside minimal side effects in vivo.