生物活性带有哌嗪酸的环状白色素类化合物，即来自于肉桂树内生链霉菌 sp. 的 Lydiamycins E-H。
Bioactive Piperazic Acid-Bearing Cyclodepsipeptides, Lydiamycins E-H, from an Endophytic Streptomyces sp. Associated with Cinnamomum cassia.
发表日期：2023 Feb 22
作者：
Weihong Wang, Seungjin Kim, Thi Hanh Nguyen Vu, Ngoc Tung Quach, Eunseok Oh, Kyu-Hyung Park, Chanyoon Park, Youbin Cho, Hyeseon Jang, Eun Roh, JunI Lee, Eunmo Kang, SongJoo Han, Quyet-Tien Phi, Heonjoong Kang
来源：
JOURNAL OF NATURAL PRODUCTS
摘要：
与药用植物肉桂(Cinnamomum cassia Presl)相关的内生放线菌Streptomyces sp. HBQ95的化学研究发现了四种新的带有吡啶基酸的环脱肽类化合物——莱迪心菌素E至H（1-4号化合物）以及一种已知化合物莱迪心菌素A。利用光谱分析和多种化学操作手段确定了它们的化学结构及其绝对构型。莱迪心菌素F至H（2-4号化合物）和A（5号化合物）对人胰腺癌细胞PANC-1具有抗转移活性且对细胞无显著毒性。
A chemical investigation of the endophytic Streptomyces sp. HBQ95, associated with the medicinal plant Cinnamomum cassia Presl, enabled the discovery of four new piperazic acid-bearing cyclodepsipeptides, lydiamycins E-H (1-4), and one known compound (lydiamycin A). Their chemical structures, including absolute configurations, were defined by a combination of spectroscopic analyses and multiple chemical manipulations. Lydiamycins F-H (2-4) and A (5) exhibited antimetastatic activity against PANC-1 human pancreatic cancer cells without significant cytotoxicity.