放射疗法通过电离辐射损伤癌细胞，导致其死亡。然而，辐射诱发的毒性限制了施加给肿瘤的放疗剂量，从而限制了放射治疗对肿瘤生长的控制效果。此外，放疗引起的延迟毒性显著危害患者的身心健康。FLASH-RT是一种新兴的放疗方法，它产生一种被称为“FLASH效应”的现象，以超高剂量速率进行放疗，对正常组织毒性较小，可实现局部肿瘤控制。版权所有 © 2023 Elsevier Ltd.

Radiation therapy damages cancer cells with ionizing radiation, leading to their death. However, radiation‑induced toxicity limits the dose delivered to the tumor, thereby constraining the control effect of radiotherapy n tumor growth. In addition, the delayed toxicity caused by radiotherapy significantly harms the physical and mental health of patients. FLASH‑RT, an emerging class of radiotherapy, causes a phenomenon known as the 'FLASH effect', which delivers radiotherapy at an ultra‑high dose rate with lower toxicity to normal tissue than conventional radiotherapy to achieve local tumor control.Copyright © 2023 Elsevier Ltd. All rights reserved.