尽管某些研究已经评估了计算机断层扫描（CT）特征与非小细胞肺癌（NSCLC）患者中的激酶（ALK）重排之间的相关性，但很少有研究关注早期患者。一些之前的研究结果不一致且相互矛盾。因此，本研究旨在分析携带ALK重排的早期NSCLC患者的临床病理学和CT特征。这项回顾性分析涵盖了65名携带ALK重排和629名ALK阴性的患者。所有患者均接受了手术切除的NSCLC，并被诊断为IA或IIB期的NSCLC。根据不同的基因型，研究临床病理学特征和CT征象，包括肿瘤大小和密度、实变肿瘤比例（CTR）、病变位置、圆形或不规则形状、分叶或刺绣边缘、气管支气管、泡状透亮或空洞以及胸膜缩回。 早期NSCLC患者ALK重排的患病率为9.3％（65/694）。带有ALK重排的患者明显年轻于无ALK重排的患者（P = 0.033）。中等细胞分化的比例在ALK重排的肿瘤中明显低于无ALK重排的肿瘤（46.2％ vs. 59.8％，P = 0.034）。粘液亚型的比例在ALK阳性组中明显高于ALK阴性组（13.8％ vs. 5.4％，P = 0.007）。未发现任何CT征象在ALK阳性组和ALK阴性组之间有显着差异。 AL K阳性肺癌患者可能具有特定的临床病理学特征，包括年轻、中等细胞分化比例低以及粘液亚型比例高。CT特征可能与早期肺癌中的ALK重排不相关。需要免疫组织化学或下一代测序进一步澄清基因突变状态。©2023年，作者（们）。

Although some studies have assessed the correlation between computed tomography (CT) features and anaplastic lymphoma kinase (ALK) rearrangement in patients with non-small-cell lung cancer (NSCLC), few have focused on early-stage patients. The results of some previous studies are inconsistent and contradictory. Therefore, this study aimed to analyze the clinicopathological and CT features of patients with early-stage NSCLC harboring ALK rearrangement.This retrospective analysis included 65 patients with ALK rearrangement and 629 ALK-negative patients. All patients had surgically resected NSCLC and were diagnosed with stage IA or stage IIB NSCLC. Clinicopathological features and CT signs, including tumor size and density, consolidation tumor ratio (CTR), lesion location, round or irregular shape, lobulated or spiculated margins, air bronchograms, bubble-like lucency or cavities, and pleural retraction, were investigated according to different genotypes.The prevalence of ALK rearrangement in patients with early-stage NSCLC was 9.3% (65/694). Patients with ALK rearrangement were significantly younger than those without ALK rearrangement (P = 0.033). The frequency of moderate cell differentiation was significantly lower in tumors with ALK rearrangement than in those without ALK rearrangement (46.2% vs. 59.8%, P = 0.034). The frequency of the mucinous subtype was significantly higher in the ALK-positive group than in the ALK-negative group (13.8% vs. 5.4%, P = 0.007). No significant differences were found in any CT signs between the ALK-positive and ALK-negative groups.Patients with ALK-positive lung cancer may have specific clinicopathological features, including younger age, lower frequency of moderate cell differentiation, and higher frequency of the mucinous type. CT features may not correlate with ALK rearrangement in early-stage lung cancer. Immunohistochemistry or next-generation sequencing is needed to further clarify the genomic mutation status.© 2023. The Author(s).