将能量平衡研究从实验室转化为临床和社区:癌症平行动物人类研究。
Translating energy balance research from the bench to the clinic to the community: Parallel animal-human studies in cancer.
发表日期:2023 Feb 24
作者:
Miriam B Garcia, Keri L Schadler, Joya Chandra, Steven K Clinton, Kerry S Courneya, Zobeida Cruz-Monserrate, Carrie R Daniel, Andrew J Dannenberg, Wendy Demark-Wahnefried, Mark W Dewhirst, Carol J Fabian, Stephen D Hursting, Melinda L Irwin, Neil M Iyengar, Jennifer L McQuade, Kathryn H Schmitz, Karen Basen-Engquist
来源:
CA-A CANCER JOURNAL FOR CLINICIANS
摘要:
能源平衡和癌症研究的进展迄今主要是在啮齿动物或患者的孤立工作中发生的。然而,可以从平行研究中获得实质性的益处,其中动物模型指导临床和人群研究的设计,或者临床观察成为动物研究的基础。2021年7月召开了“从实验室到社区:应用平行动物人类研究在癌症中的应用”会议,召集了基础、翻译/临床和人口科学研究的调查人员,以分享知识、成功的平行研究示例和强大的研究成果,以推动能源平衡和癌症领域朝着实践变革的方向发展。本综述总结了讨论的关键主题,以推进关于能量平衡、包括身体活动、身体构成和饮食摄入等对癌症发展、癌症结果和健康康复的作用的研究。©2023年作者。代表美国癌症协会的Wiley Periodicals LLC出版的CA:癌症临床杂志发表。
Advances in energy balance and cancer research to date have largely occurred in siloed work in rodents or patients. However, substantial benefit can be derived from parallel studies in which animal models inform the design of clinical and population studies or in which clinical observations become the basis for animal studies. The conference Translating Energy Balance from Bench to Communities: Application of Parallel Animal-Human Studies in Cancer, held in July 2021, convened investigators from basic, translational/clinical, and population science research to share knowledge, examples of successful parallel studies, and strong research to move the field of energy balance and cancer toward practice changes. This review summarizes key topics discussed to advance research on the role of energy balance, including physical activity, body composition, and dietary intake, on cancer development, cancer outcomes, and healthy survivorship.© 2023 The Authors. CA: A Cancer Journal for Clinicians published by Wiley Periodicals LLC on behalf of American Cancer Society.